SAE1 information

SAE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y8Q, 1Y8R, 3KYC, 3KYD
Identifiers
Aliases	SAE1, AOS1, HSPC140, SUA1, UBLE1A, SUMO1 activating enzyme subunit 1
External IDs	OMIM: 613294; MGI: 1929264; HomoloGene: 4019; GeneCards: SAE1; OMA:SAE1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	47,210,636 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	16,121,731 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; muscle layer of sigmoid colon; ; stromal cell of endometrium; ; left testis; ; right testis; ; gonad; ; oocyte; ; prefrontal cortex; ; smooth muscle tissue;
	Top expressed in
	ventricular zone; ; epiblast; ; primitive streak; ; somite; ; abdominal wall; ; mandibular prominence; ; neural tube; ; maxillary prominence; ; yolk sac; ; tail of embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin activating enzyme activity; SUMO activating enzyme activity; enzyme activator activity; ligase activity; protein C-terminus binding; ubiquitin-like modifier activating enzyme activity; protein binding; ATP-dependent protein binding; small protein activating enzyme binding; protein heterodimerization activity;
Cellular component	SUMO activating enzyme complex; nucleus; nucleoplasm; cytoplasm;
Biological process	protein sumoylation; protein ubiquitination; positive regulation of protein targeting to mitochondrion; positive regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	10055
	56459
	ENSG00000142230
	ENSMUSG00000052833
	Q9UBE0
	Q9R1T2
	NM_001145713; NM_001145714; NM_005500
	NM_001285891; NM_001285892; NM_019748
	NP_001139185; NP_001139186; NP_005491
	NP_001272820; NP_001272821; NP_062722
	Wikidata
View/Edit Human	View/Edit Mouse

SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142230 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052833 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Desterro JM, Rodriguez MS, Kemp GD, Hay RT (May 1999). "Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1". J. Biol. Chem. 274 (15): 10618–24. doi:10.1074/jbc.274.15.10618. PMID 10187858.
^ Okuma T, Honda R, Ichikawa G, Tsumagari N, Yasuda H (Mar 1999). "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2". Biochem. Biophys. Res. Commun. 254 (3): 693–8. doi:10.1006/bbrc.1998.9995. PMID 9920803.
^ Gong L, Li B, Millas S, Yeh ET (Jun 1999). "Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex". FEBS Lett. 448 (1): 185–9. doi:10.1016/S0014-5793(99)00367-1. PMID 10217437. S2CID 7756078.
^ "Entrez Gene: SAE1 SUMO1 activating enzyme subunit 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142230 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052833 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10187858-5] Desterro JM, Rodriguez MS, Kemp GD, Hay RT (May 1999). "Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1". J. Biol. Chem. 274 (15): 10618–24. doi:10.1074/jbc.274.15.10618. PMID 10187858.

[pmid9920803-6] Okuma T, Honda R, Ichikawa G, Tsumagari N, Yasuda H (Mar 1999). "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2". Biochem. Biophys. Res. Commun. 254 (3): 693–8. doi:10.1006/bbrc.1998.9995. PMID 9920803.

[pmid10217437-7] Gong L, Li B, Millas S, Yeh ET (Jun 1999). "Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex". FEBS Lett. 448 (1): 185–9. doi:10.1016/S0014-5793(99)00367-1. PMID 10217437. S2CID 7756078.

[entrez-8] "Entrez Gene: SAE1 SUMO1 activating enzyme subunit 1".

SAE1 information

and 25 Related for: SAE1 information

SAE1

Signal peptide

Protein targeting

Ubiquitin ligase

Protein folding

Heat shock protein

SUMO protein

Three Kingdoms

Chaperonin

Varieties of Chinese

Ubiquitin

Survival of motor neuron

Target peptide

Myc

ISG15

Neddylation

Binding immunoglobulin protein

ATG8

Clusterin

Cullin

Mdm2

Hsp33

Hsp70

Succinylation

Deubiquitinating enzyme