RAD21 information

RAD21
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PJU, 4PJW, 4PK7
Identifiers
Aliases	RAD21, CDLS4, HR21, HMCD1, NXP1, SCC1, hHR21, RAD21 cohesin complex component, MGS
External IDs	OMIM: 606462; MGI: 108016; HomoloGene: 38161; GeneCards: RAD21; OMA:RAD21 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	116,874,776 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	51,855,143 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; superficial temporal artery; ; germinal epithelium; ; cerebellar vermis; ; subthalamic nucleus; ; trabecular bone; ; inferior ganglion of vagus nerve; ; seminal vesicula; ; superior vestibular nucleus; ; corpus callosum;
	Top expressed in
	left lung lobe; ; hand; ; dermis; ; medial ganglionic eminence; ; abdominal wall; ; atrium; ; cerebellar vermis; ; vas deferens; ; dorsomedial hypothalamic nucleus; ; maxillary prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; chromatin binding; protein-containing complex binding;
Cellular component	cytosol; membrane; chromosome; nucleoplasm; condensed nuclear chromosome; nuclear chromosome; chromatin; chromosome, centromeric region; nucleus; cohesin complex; nuclear matrix; meiotic cohesin complex; spindle pole; cytoplasm; cytoskeleton;
Biological process	reciprocal meiotic recombination; DNA recombination; chromosome segregation; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; cellular response to DNA damage stimulus; cell division; double-strand break repair; cell cycle; protein localization to chromatin; DNA repair; positive regulation of transcription by RNA polymerase II; apoptotic process; sister chromatid cohesion; positive regulation of sister chromatid cohesion; negative regulation of G2/M transition of mitotic cell cycle; negative regulation of mitotic metaphase/anaphase transition; meiosis; multicellular organism development;
	Sources:Amigo / QuickGO
Orthologs
	5885
	19357
	ENSG00000164754
	ENSMUSG00000022314
	O60216
	Q61550
	NM_006265
	NM_009009
	NP_006256
	NP_033035
	Wikidata
View/Edit Human	View/Edit Mouse

Double-strand-break repair protein rad21 homolog is a protein that in humans is encoded by the RAD21 gene.^[5]^[6] RAD21 (also known as Mcd1, Scc1, KIAA0078, NXP1, HR21), an essential gene, encodes a DNA double-strand break (DSB) repair protein that is evolutionarily conserved in all eukaryotes from budding yeast to humans. RAD21 protein is a structural component of the highly conserved cohesin complex consisting of RAD21, SMC1A, SMC3, and SCC3 [ STAG1 (SA1) and STAG2 (SA2) in multicellular organisms] proteins, involved in sister chromatid cohesion.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164754 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022314 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McKay MJ, Troelstra C, van der Spek P, et al. (Jan 1997). "Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse". Genomics. 36 (2): 305–15. doi:10.1006/geno.1996.0466. hdl:1765/3107. PMID 8812457.
^ "Entrez Gene: RAD21 RAD21 homolog (S. pombe)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164754 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022314 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8812457-5] McKay MJ, Troelstra C, van der Spek P, et al. (Jan 1997). "Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse". Genomics. 36 (2): 305–15. doi:10.1006/geno.1996.0466. hdl:1765/3107. PMID 8812457.

[entrez-6] "Entrez Gene: RAD21 RAD21 homolog (S. pombe)".

RAD21 information

and 23 Related for: RAD21 information

RAD21

Cohesin

Cornelia de Lange syndrome

SMC3

WAPAL

List of genetic disorders

Stress granule

Shugoshin N terminal protein domain

STAG1

STAG2

SMC1A

PDS5B

Chromomere

Establishment of sister chromatid cohesion

Separase

Spindle checkpoint

Acute megakaryoblastic leukemia

SMARCA5

Transient myeloproliferative disease

SMC1B

Aurora kinase B

KIAA0196

GATA1