IRX3 information

IRX3
Identifiers
Aliases	IRX3, IRX-1, IRXB1, iroquois homeobox 3
External IDs	OMIM: 612985; MGI: 1197522; HomoloGene: 7385; GeneCards: IRX3; OMA:IRX3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	54,286,787 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	92,528,695 bp
RNA expression pattern
	Top expressed in
	nipple; ; human penis; ; skin of arm; ; myocardium of left ventricle; ; bronchial epithelial cell; ; vulva; ; epithelium of lactiferous gland; ; lactiferous duct; ; trachea; ; gingival epithelium;
	Top expressed in
	lacrimal gland; ; left lung lobe; ; maxillary prominence; ; calvaria; ; abdominal wall; ; vestibular membrane of cochlear duct; ; lactiferous gland; ; right lung; ; right lung lobe; ; right ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; axon; nucleus;
Biological process	multicellular organism development; mesoderm development; specification of loop of Henle identity; metanephros development; regulation of transcription, DNA-templated; negative regulation of neuron differentiation; positive regulation of neuron differentiation; transcription, DNA-templated; proximal/distal pattern formation involved in nephron development; regulation of transcription by RNA polymerase II; energy homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	79191
	16373
	ENSG00000177508
	ENSMUSG00000031734
	P78415
	P81067
	NM_024336
	NM_001253822; NM_008393
	NP_077312
	NP_001240751; NP_032419
	Wikidata
View/Edit Human	View/Edit Mouse

Iroquois-class homeodomain protein IRX-3, also known as Iroquois homeobox protein 3, is a protein that in humans is encoded by the IRX3 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177508 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031734 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: iroquois homeobox 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177508 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031734 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: iroquois homeobox 3".

IRX3 information

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