SOX11 information

SOX11
Identifiers
Aliases	SOX11, MRD27, SRY-box 11, CSS9, SRY-box transcription factor 11
External IDs	OMIM: 600898; MGI: 98359; HomoloGene: 37733; GeneCards: SOX11; OMA:SOX11 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	5,701,385 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	27,392,573 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; buccal mucosa cell; ; cartilage tissue; ; optic nerve; ; retinal pigment epithelium; ; internal globus pallidus; ; nucleus accumbens; ; hypothalamus; ; medulla oblongata;
	Top expressed in
	Rostral migratory stream; ; medial ganglionic eminence; ; abdominal wall; ; maxillary prominence; ; genital tubercle; ; human fetus; ; mandibular prominence; ; fossa; ; otic vesicle; ; trigeminal ganglion;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; translation factor activity, RNA binding; transcription cis-regulatory region binding; cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	cytoplasm; nucleus;
Biological process	embryonic skeletal system morphogenesis; skeletal system development; noradrenergic neuron differentiation; positive regulation of lens epithelial cell proliferation; cell differentiation; cardiac ventricle formation; glial cell development; regulation of transcription, DNA-templated; limb bud formation; lung morphogenesis; sympathetic nervous system development; neural crest cell development; kidney development; negative regulation of glial cell proliferation; soft palate development; ventricular septum morphogenesis; cornea development in camera-type eye; outflow tract morphogenesis; positive regulation of ossification; negative regulation of transcription by RNA polymerase II; negative regulation of cell death; transcription by RNA polymerase II; eyelid development in camera-type eye; negative regulation of gene expression; negative regulation of lymphocyte proliferation; somite development; transcription, DNA-templated; neuroepithelial cell differentiation; regulation of transforming growth factor beta receptor signaling pathway; nervous system development; positive regulation of transcription, DNA-templated; positive regulation of hippo signaling; positive regulation of neurogenesis; multicellular organism development; positive regulation of gene expression; positive regulation of osteoblast differentiation; lens morphogenesis in camera-type eye; negative regulation of transcription regulatory region DNA binding; hard palate development; positive regulation of neuron differentiation; neuron differentiation; positive regulation of cell population proliferation; spinal cord development; positive regulation of BMP signaling pathway; glial cell proliferation; skeletal muscle cell differentiation; embryonic digestive tract morphogenesis; oligodendrocyte development; cell population proliferation; positive regulation of stem cell proliferation; neural tube formation; positive regulation of hormone secretion; positive regulation of transcription by RNA polymerase II; closure of optic fissure; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	6664
	20666
	ENSG00000176887
	ENSMUSG00000063632
	P35716
	Q7M6Y2
	NM_003108
	NM_009234
	NP_003099
	NP_033260
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176887 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063632 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jay P, Gozé C, Marsollier C, Taviaux S, Hardelin JP, Koopman P, Berta P (Sep 1995). "The human SOX11 gene: cloning, chromosomal assignment and tissue expression". Genomics. 29 (2): 541–5. doi:10.1006/geno.1995.9970. PMID 8666406.
^ Wiebe MS, Nowling TK, Rizzino A (May 2003). "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity". The Journal of Biological Chemistry. 278 (20): 17901–11. doi:10.1074/jbc.M212211200. PMID 12637543.
^ "Entrez Gene: SOX11 SRY (sex determining region Y)-box 11".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176887 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063632 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8666406-5] Jay P, Gozé C, Marsollier C, Taviaux S, Hardelin JP, Koopman P, Berta P (Sep 1995). "The human SOX11 gene: cloning, chromosomal assignment and tissue expression". Genomics. 29 (2): 541–5. doi:10.1006/geno.1995.9970. PMID 8666406.

[pmid12637543-6] Wiebe MS, Nowling TK, Rizzino A (May 2003). "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity". The Journal of Biological Chemistry. 278 (20): 17901–11. doi:10.1074/jbc.M212211200. PMID 12637543.

[entrez-7] "Entrez Gene: SOX11 SRY (sex determining region Y)-box 11".

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