Rupatadine information

Rupatadine
Clinical data
Trade names	Rupafin, others
AHFS/Drugs.com	International Drug Names
Routes of; administration	By mouth
ATC code	R06AX28 (WHO) ;
Legal status
Legal status	CA: ℞-only; EU: Rx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Protein binding	98–99%
Metabolism	Liver, CYP-mediated
Elimination half-life	5.9 hours
Excretion	34.6% urine, 60.9% faeces
Identifiers
	IUPAC name 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-5H-benzo[5,6]cyclohepta[1,2-b]pyridine fumarate;
CAS Number	158876-82-5 (free base); 182349-12-8 (fumarate);
PubChem CID	133017;
DrugBank	DB11614 ;
ChemSpider	117388 ;
UNII	2AE8M83G3E;
KEGG	D07407 ;
ChEBI	CHEBI:135673;
ChEMBL	ChEMBL91397 ;
CompTox Dashboard (EPA)	DTXSID00166534 ;
ECHA InfoCard	100.260.389
Chemical and physical data
Formula	C26H26ClN3
Molar mass	415.97 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1cc5c(cc1)\C(=C3/CCN(Cc2cncc(c2)C)CC3)c4ncccc4CC5;
	InChI InChI=1S/C26H26ClN3/c1-18-13-19(16-28-15-18)17-30-11-8-20(9-12-30)25-24-7-6-23(27)14-22(24)5-4-21-3-2-10-29-26(21)25/h2-3,6-7,10,13-16H,4-5,8-9,11-12,17H2,1H3 ; Key:WUZYKBABMWJHDL-UHFFFAOYSA-N ;
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Rupatadine is a second generation antihistamine and platelet-activating factor antagonist used to treat allergies. It was discovered and developed by Uriach [es]^[3] and is marketed as Rupafin and under several other trade names.

^ "Health Canada New Drug Authorizations: 2016 Highlights". Health Canada. 14 March 2017. Retrieved 7 April 2024.
^ "Active Substance: rupatadine" (PDF). List of the nationally authorised medicinal products. European Medicines Agency. 2 September 2021. Archived (PDF) from the original on 28 November 2023. Retrieved 3 September 2021.
^ Patents: EP 577957 , US 5407941 , US 5476856

[1] "Health Canada New Drug Authorizations: 2016 Highlights". Health Canada. 14 March 2017. Retrieved 7 April 2024.

[2] "Active Substance: rupatadine" (PDF). List of the nationally authorised medicinal products. European Medicines Agency. 2 September 2021. Archived (PDF) from the original on 28 November 2023. Retrieved 3 September 2021.

[3] Patents: EP 577957 , US 5407941 , US 5476856

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