The trifluoromethoxy group is the chemical group –O–CF 3. It can be seen as a methoxy group –O–CH 3 whose hydrogen atoms are replaced by fluorine atoms; or as a trifluoromethyl group attached to the rest of the molecule by a bridging oxygen atom; either leads to viable syntheses.[1] Compounds having this functional group are of some relevance as pharmaceuticals. One example is riluzole.
^Synthetic Approaches to Trifluoromethoxy-Substituted Compounds A. Tlili, F. Toulgoat, T. Billard, Angew. Chem. Int. Ed. 2016, 55, 11726–11735; doi:10.1002/anie.201603697
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The trifluoromethoxygroup is the chemical group –O–CF 3. It can be seen as a methoxy group –O–CH 3 whose hydrogen atoms are replaced by fluorine atoms;...
with Ruppert's reagent. Trifluromethyl cation Trichloromethyl groupTrifluoromethoxygroup Fluoroethyl Jan E. True; T. Darrah Thomas; Rolf W. Winter; Gary...
functional group is a substituent or moiety in a molecule that causes the molecule's characteristic chemical reactions. The same functional group will undergo...
In organic chemistry, an ethyl group (abbr. Et) is an alkyl substituent with the formula −CH2CH3, derived from ethane (C2H6). Ethyl is used in the International...
a variety of carbon-containing substituents. Ketones contain a carbonyl group −C(=O)− (which contains a carbon–oxygen double bond C=O). The simplest ketone...
phenethylamine hallucinogen mescaline, which has a trifluoromethoxygroup replacing the central methoxy group of mescaline. Synthesis of this compound was first...
group, or phenyl ring, is a cyclic group of atoms with the formula C6H5, and is often represented by the symbol Ph (archaically φ). The phenyl group is...
development was discontinued. CP-122721 was a CP-99994 analog that had a trifluoromethoxygroup in the o-methoxybenzyl ring. It entered phase II trials for the...
In organic chemistry, an alkyl group is an alkane missing one hydrogen. The term alkyl is intentionally unspecific to include many possible substitutions...
amines (/əˈmiːn, ˈæmiːn/, UK also /ˈeɪmiːn/) are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally...
In organic chemistry, a vinyl group (abbr. Vi; IUPAC name: ethenyl group) is a functional group with the formula −CH=CH2. It is the ethylene (IUPAC name:...
organyl group (R−C=O) or hydrogen in the case of formyl group (H−C=O). In organic chemistry, the acyl group (IUPAC name alkanoyl if the organyl group is alkyl)...
For organic chemistry, a carbonyl group is a functional group with the formula C=O, composed of a carbon atom double-bonded to an oxygen atom, and it...
In chemistry, a hydroxy or hydroxyl group is a functional group with the chemical formula −OH and composed of one oxygen atom covalently bonded to one...
functional group with the formula −COC6H5 and structure −C(=O)−C6H5. It can be viewed as benzaldehyde missing one hydrogen. The benzoyl group has a mass...
contain one or more nitro functional groups (−NO2). The nitro group is one of the most common explosophores (functional group that makes a compound explosive)...
carboxylic acid is an organic acid that contains a carboxyl group (−C(=O)−OH) attached to an R-group. The general formula of a carboxylic acid is often written...
called ethanoyl. The acetyl group contains a methyl group (−CH3) single-bonded to a carbonyl (C=O), making it an acyl group. The carbonyl center of an...
R−CH2−C6H5. Benzyl features a benzene ring (C6H6) attached to a methylene group (−CH2−) group. In IUPAC nomenclature, the prefix benzyl refers to a C6H5CH2 substituent...
alkoxy group is an alkyl group which is singularly bonded to oxygen; thus R−O. Denoted usually with apostrophe('). The range of alkoxy groups is vast...
In formulas, the group is often abbreviated as Me. This hydrocarbon group occurs in many organic compounds. It is a very stable group in most molecules...
In chemistry, peroxides are a group of compounds with the structure R−O−O−R, where the R's represent any element and O's are single oxygen molecules....
organic chemistry, butyl is a four-carbon alkyl radical or substituent group with general chemical formula −C4H9, derived from either of the two isomers...
A methylene group is any part of a molecule that consists of two hydrogen atoms bound to a carbon atom, which is connected to the remainder of the molecule...
In organosulfur chemistry, a sulfonyl group can refer either to a functional group found primarily in sulfones, or to a substituent obtained from a sulfonic...
an allyl group is a substituent with the structural formula −CH2−HC=CH2. It consists of a methylene bridge (−CH2−) attached to a vinyl group (−CH=CH2)...
substituent. The −SH functional group itself is referred to as either a thiol group or a sulfhydryl group, or a sulfanyl group. Thiols are the sulfur analogue...
organic chemistry, a methoxy group is the functional group consisting of a methyl group bound to oxygen. This alkoxy group has the formula R−O−CH3. On...
In organic chemistry, the acetoxy group (abbr. AcO or OAc; IUPAC name: acetyloxy), is a functional group with the formula −OCOCH3 and the structure −O−C(=O)−CH3...
In organic chemistry, a methine group or methine bridge is a trivalent functional group =CH−, derived formally from methane. It consists of a carbon atom...
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