White or translucent crystal or crystalline powder; Bitter tasting
Odor
Odorless
Density
1.36 g cm−3
Melting point
270 °C; 518 °F; 543 K
Boiling point
284 to 286 °C; 543 to 547 °F; 557 to 559 K
Solubility in water
0.02% (20°C)[2]
Acidity (pKa)
8.25[3]
Pharmacology
Legal status
BR: Class F4 (Other prohibited substances)[4]
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
Extremely toxic
GHS labelling:
Pictograms
Signal word
Danger
Hazard statements
H300, H310, H330, H410
Precautionary statements
P260, P264, P273, P280, P284, P301+P310
NFPA 704 (fire diamond)
4
0
0
Flash point
Non flammable
Autoignition temperature
Non flammable
Lethal dose or concentration (LD, LC):
LD50 (median dose)
0.5 mg/kg (dog, oral)
0.5 mg/kg (cat, oral)
2 mg/kg (mouse, oral)
16 mg/kg (rat, oral)
2.35 mg/kg (rat, oral)[5]
LDLo (lowest published)
0.6 mg/kg (rabbit, oral)[5]
NIOSH (US health exposure limits):
PEL (Permissible)
TWA 0.15 mg/m3[2]
REL (Recommended)
TWA 0.15 mg/m3[2]
IDLH (Immediate danger)
3 mg/m3[2]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound
Strychnine (/ˈstrɪkniːn,-nɪn/, STRIK-neen, -nin, US chiefly /-naɪn/-nyne)[6][7] is a highly toxic, colorless, bitter, crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents. Strychnine, when inhaled, swallowed, or absorbed through the eyes or mouth, causes poisoning which results in muscular convulsions and eventually death through asphyxia.[8] While it is no longer used medicinally, it was used historically in small doses to strengthen muscle contractions, such as a heart and bowel stimulant[9] and performance-enhancing drug. The most common source is from the seeds of the Strychnos nux-vomica tree.
^Retrieved from SciFinder. [May 7, 2018]
^ abcdCite error: The named reference PGCH was invoked but never defined (see the help page).
^Everett AJ, Openshaw HT, Smith GF (1957). "The constitution of aspidospermine. Part III. Reactivity at the nitrogen atoms, and biogenetic considerations". Journal of the Chemical Society: 1120–1123. doi:10.1039/JR9570001120. S2CID 94111547.
^Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
^ ab"Strychnine". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
^Jones D (2011). Roach P, Setter J, Esling J (eds.). Cambridge English Pronouncing Dictionary (18th ed.). Cambridge University Press. ISBN 978-0-521-15255-6.
^Sharma RK (2007). "Spinal Poisons". Concise Textbook of Forensic Medicine & Toxicology (2nd ed.). Elsevier. pp. 306–308. ISBN 978-81-312-1145-8.
^Munro J (1914-04-18). "Veronal Poisoning: Case of Recovery from 125 Grains". British Medical Journal. 1 (2781): 854–856. doi:10.1136/bmj.1.2781.854. ISSN 0007-1447. PMC 2300683. PMID 20767090. S2CID 41592291. An attempt was made to administer a soap-and-water enema, but the sphincter was not acting. After hypodermic injection of 1/45 grain [1.44 mg] strychnine, a second attempt was made, and a good evacuation of the bowel followed, after which half a pint [284 ml] of normal saline was injected and retained. [...] We decided to adhere to the treatment already commenced – namely, periodical rectal injection of saline and withdrawals of urine by catheter, with oxygen inhalation for cyanosis, and strychnine hypodermically as the pulse weakened.
Strychnine (/ˈstrɪkniːn, -nɪn/, STRIK-neen, -nin, US chiefly /-naɪn/ -nyne) is a highly toxic, colorless, bitter, crystalline alkaloid used as a pesticide...
Strychnine poisoning can be fatal to humans and other animals and can occur by inhalation, swallowing or absorption through eyes or mouth. It produces...
Strychnine total synthesis in chemistry describes the total synthesis of the complex biomolecule strychnine. The first reported method by the group of...
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The Strychnine Babies were an American punk rock band formed in Philadelphia, Pennsylvania, United States, by Christian Martucci, Eric Bowr, and punk rock...
related to strychnine, most commonly found in the Strychnos nux-vomica tree. Brucine poisoning is rare, since it is usually ingested with strychnine, and strychnine...
Dance Hall at Louse Point is the debut collaborative studio album by English alternative rock musicians PJ Harvey and John Parish, released on 23 September...
seeds of the strychnine tree (Strychnos nux-vomica) and in the genus catharanthus. The seeds of the strychnine tree contain up to 2.5% strychnine and brucine...
operated the university almost single-handedly until her unsolved murder by strychnine poisoning in 1905. She was the eighth First Lady of California. Her husband...
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atropine is isolated from the plant Atropa belladonna; strychnine is obtained from the seed of the Strychnine tree (Strychnos nux-vomica L.). Where several alkaloids...
muscles that appears to produce grinning. It may be caused by tetanus, strychnine poisoning, or Wilson's disease, and has been reported after execution...
surface of the liver. Certain substances, such as carbolic acid, arsenic, strychnine, and zinc chloride, can be used to delay the process of putrefaction in...
as Saint Ignatius' beans. The beans of the plant contain the alkaloids strychnine and brucine. Ignatia. enotes.com Archived March 4, 2011, at the Wayback...
"Strychnine in the Soup" is a short story by the British comic writer P. G. Wodehouse. A part of the Mr. Mulliner series, the story was first published...
Wilding joined Belgian death metal act Aborted. With them he had recorded Strychnine.213, released in 2008. In 2009 he left Aborted and joined UK technical...
structural formula of strychnine was determined only in 1947, although the presence of the indole nucleus in the structure of strychnine was established somewhat...
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songs "The Witch" (a minor regional hit), "Psycho", "Boss Hoss" and "Strychnine", along with an assortment of rock and roll and R&B covers. Here Are The...
example, in 1904, Thomas Hicks, a gold medallist in the marathon, was given strychnine by his coach (at the time, taking different substances was allowed, as...
species. Among these alkaloids are the well-known and virulent poisons strychnine and curare. The name strychnos was applied by Pliny the Elder in his Natural...
caffeine, lidocaine, benzocaine, paracetamol, amphetamine, scopolamine and strychnine. Smoking problems: Any route of administration poses its own set of health...
the active site but cannot be broken down, so hydrolysis cannot occur. Strychnine is a neurotoxin that causes death by affecting nerves that control muscular...
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