Protein topology information

Protein topology is a property of protein molecule that does not change under deformation (without cutting or breaking a bond). Two main topology frameworks...

polytopic proteins are transmembrane proteins that span across the membrane more than once. These proteins may have different transmembrane topology. These...

Circuit topology have been applied to characterise protein topology. Being able to describe protein topology opens up new pathways for protein engineering...

Topology of a transmembrane protein refers to locations of N- and C-termini of membrane-spanning polypeptide chain with respect to the inner or outer...

joining proteins sharing these fragments into protein superfamilies is no longer justified. Topology of a protein can be used to classify proteins as well...

too can be said to be directional. They are usually represented in protein topology diagrams by an arrow pointing toward the C-terminus. Adjacent β-strands...

as pore-forming toxins. All beta-barrel transmembrane proteins have simplest up-and-down topology, which may reflect their common evolutionary origin and...

molecular biology, protein fold classes are broad categories of protein tertiary structure topology. They describe groups of proteins that share similar...

Topology (from the Greek words τόπος, 'place, location', and λόγος, 'study') is the part of mathematics concerned with the properties of a geometric object...

are established via protein bridges including CTCF and cohesins and are measured by technologies including Hi-C. Circuit topology categorises the topological...

viruses' E protein pentamers have been structurally characterized by nuclear magnetic resonance spectroscopy. The membrane topology of the E protein has been...

"transmembrane topology" of a protein; i.e. prediction of what parts of it protrude into the cell, what parts protrude out, and how many times the protein chain...

size and known structure, Rop has been used in protein design work to rearrange its helical topology and reengineer its loop regions. In general, the...

protein depends on its size, contact order, and circuit topology. Understanding and simulating the protein folding process has been an important challenge for...

Transmembrane protein 212 is a protein that in humans is encoded by the TMEM212 gene. The protein consists of five transmembrane domains and localizes...

DeepMind, the structure prediction module achieved a correct topology for the target protein on its first iteration, scored as having a GDT_TS of 78, but...

It is encoded by the spa gene and its regulation is controlled by DNA topology, cellular osmolarity, and a two-component system called ArlS-ArlR. It has...

recombinant protein production". Current Opinion in Structural Biology. New constructs and expression of proteins / Sequences and topology. 26: 39–43....

detect topology-independent similarities. In 1979, Bruce Cunningham and his colleagues discovered the first instance of a circularly permuted protein in nature...

memsat_svm is used to predict the presence and topology of any transmembrane helices present in the user protein sequence. Phyre2 permits users to choose 'Intensive'...

Heijne G, Sonnhammer EL (January 2001). "Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes". J. Mol...

Gunnar; Sonnhammer, Erik L.L (Jan 2001). "Predicting transmembrane protein topology with a hidden markov model: application to complete genomes". Journal...

which has always held for mammalian proteins targeted to the ER. A great deal of the mechanics of transmembrane topology and folding remains to be elucidated...

(topology) a type of architecture that also has a conserved loop structure. Blocks is a conserved amino acid sequence pattern in a family of proteins....

Myelin proteolipid protein (PLP or lipophilin) is the major myelin protein from the central nervous system (CNS). It plays an important role in the formation...

these proteins, topological approaches have been developed to search for conformational patterns in their dynamics. For instance, circuit topology has been...