Tertiary structure prediction tool for protein sequence
Phyre2
Developer(s)
Lawrence Kelley
Bob Maccallum
Benjamin Jefferys
Alex Herbert
Riccardo Bennett-Lovsey
Michael Sternberg
Stable release
2.0
/ 23 February 2011; 13 years ago (2011-02-23)
Written in
C++
Perl
Python
Available in
English
Type
Bioinformatics tool for protein structure prediction
License
Creative Commons Attribution-2.0
Website
www.sbg.bio.ic.ac.uk/phyre2
Phyre and Phyre2 (Protein Homology/AnalogYRecognition Engine; pronounced as 'fire') are free web-based services for protein structure prediction.[1][2][3] Phyre is among the most popular methods for protein structure prediction having been cited over 1500 times.[4] Like other remote homology recognition techniques (see protein threading), it is able to regularly generate reliable protein models when other widely used methods such as PSI-BLAST cannot. Phyre2 has been designed to ensure a user-friendly interface for users inexpert in protein structure prediction methods. Its development is funded by the Biotechnology and Biological Sciences Research Council.[5]
^Lawrence Kelley; Riccardo Bennett-Lovsey; Alex Herbert; Kieran Fleming. "Phyre: Protein Homology/analogY Recognition Engine". Structural Bioinformatics Group, Imperial College, London. Retrieved 22 April 2011.
^Lawrence Kelley; Benjamin Jefferys. "Phyre2: Protein Homology/analogY Recognition Engine V 2.0". Structural Bioinformatics Group, Imperial College, London. Retrieved 22 April 2011.
^Kelley, L. A.; Sternberg, M. J. E. (2009). "Protein structure prediction on the Web: A case study using the Phyre server" (PDF). Nature Protocols. 4 (3): 363–71. doi:10.1038/nprot.2009.2. hdl:10044/1/18157. PMID 19247286. S2CID 12497300.
^Number of results returned from a search on Google Scholar (Google Scholar search)
^"Help: About PHYRE2". PHYRE Protein Fold Recognition Server. The work on developing the Phyre2 web server is supported by a BBSRC tools and resources grant
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