A summary of functional annotation of the most ancestral translation protein folds
In molecular biology, protein fold classes are broad categories of protein tertiary structure topology. They describe groups of proteins that share similar amino acid and secondary structure proportions. Each class contains multiple, independent protein superfamilies (i.e. are not necessarily evolutionarily related to one another).[1][2][3]
^Hubbard, Tim J. P.; Murzin, Alexey G.; Brenner, Steven E.; Chothia, Cyrus (1997-01-01). "SCOP: a Structural Classification of Proteins database". Nucleic Acids Research. 25 (1): 236–239. doi:10.1093/nar/25.1.236. ISSN 0305-1048. PMC 146380. PMID 9016544.
^Greene, Lesley H.; Lewis, Tony E.; Addou, Sarah; Cuff, Alison; Dallman, Tim; Dibley, Mark; Redfern, Oliver; Pearl, Frances; Nambudiry, Rekha (2007-01-01). "The CATH domain structure database: new protocols and classification levels give a more comprehensive resource for exploring evolution". Nucleic Acids Research. 35 (suppl 1): D291–D297. doi:10.1093/nar/gkl959. ISSN 0305-1048. PMC 1751535. PMID 17135200.
^Fox, Naomi K.; Brenner, Steven E.; Chandonia, John-Marc (2014-01-01). "SCOPe: Structural Classification of Proteins—extended, integrating SCOP and ASTRAL data and classification of new structures". Nucleic Acids Research. 42 (D1): D304–D309. doi:10.1093/nar/gkt1240. ISSN 0305-1048. PMC 3965108. PMID 24304899.
and 28 Related for: Protein fold class information
molecular biology, proteinfoldclasses are broad categories of protein tertiary structure topology. They describe groups of proteins that share similar...
Proteinfolding is the physical process by which a protein, after synthesis by a ribosome as a linear chain of amino acids, changes from an unstable random...
a protein. For simple proteins, it can be the entire protein. The broadest groups on SCOP version 1.75 are the proteinfoldclasses. These classes group...
predict protein folding and thus protein structure, for example, Itasser, and AlphaFold. AlphaFold was one of the first AIs to predict protein structures....
proteins. There are multiple fold classes of globular proteins, since there are many different architectures that can fold into a roughly spherical shape...
AlphaFold is an artificial intelligence (AI) program developed by DeepMind, a subsidiary of Alphabet, which performs predictions of protein structure....
Small proteins are a diverse foldclass of proteins (usually <100 amino acids long). Their tertiary structure is usually maintained by disulphide bridges...
heme-containing globular proteins, involved in binding and/or transporting oxygen. These proteins all incorporate the globin fold, a series of eight alpha...
The jelly roll or Swiss roll fold is a proteinfold or supersecondary structure composed of eight beta strands arranged in two four-stranded sheets. The...
finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) which stabilizes the fold. It was originally...
proteinfolding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains...
helix/beta sheet proteins. While most proteins adopt a single stable fold, a few proteins can rapidly interconvert between one or more folds. These are referred...
assisting proteinfolding. HSP60 belong to a large class of molecules that assist proteinfolding, called molecular chaperones. Newly made proteins usually...
In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest...
change can impact the protein's ability to function or to fold correctly. Misfolded proteins have a tendency to form dense protein clumps, which are often...
identified as a peptide, rather than a protein. To be able to perform their biological function, proteinsfold into one or more specific spatial conformations...
pathways within cells that control the biogenesis, folding, trafficking, and degradation of proteins present within and outside the cell. Loss of proteostasis...
transformer protein (TFP) also known as a metamorphic protein is a protein that can interconvert between two or more shapes (also known as folds) each having...
proteins that assist other proteins in assuming their three-dimensional fold, which is necessary for protein function. However, the fold of a protein...
transcription, translation, post translational modifications, and proteinfolding. Proteins are made from amino acids. In humans, some amino acids can be...
isomerase), also known as an alpha/beta barrel,: 252 is a conserved proteinfold consisting of eight alpha helices (α-helices) and eight parallel beta...
help of an MHC class I protein. Because MHC class I molecules present peptides derived from cytosolic proteins, the pathway of MHC class I presentation...
Chemical chaperones are a class of small molecules that function to enhance the folding and/or stability of proteins. Chemical chaperones are a broad and...
perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress. This...
methods have a reasonable probability of predicting the folds of small, single-domain proteins within 1.5 angstroms over the entire structure. De novo...
elements typically spontaneously form as an intermediate before the proteinfolds into its three dimensional tertiary structure. Secondary structure is...
multi-domain proteins. They are sometimes considered as a separate class of proteins along with globular, fibrous and membrane proteins. IDPs are a very...
The CATH Protein Structure Classification database is a free, publicly available online resource that provides information on the evolutionary relationships...
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