A transmembrane domain (TMD) is a membrane-spanning protein domain. TMDs may consist of one or several alpha-helices or a transmembrane beta barrel. Because the interior of the lipid bilayer is hydrophobic, the amino acid residues in TMDs are often hydrophobic, although proteins such as membrane pumps and ion channels can contain polar residues. TMDs vary greatly in size and hydrophobicity; they may adopt organelle-specific properties.[1]
^Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter (2002). "Membrane Proteins". Molecular Biology of the Cell. 4th Edition.
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A transmembranedomain (TMD) is a membrane-spanning protein domain. TMDs may consist of one or several alpha-helices or a transmembrane beta barrel. Because...
recognition domain, an extracellular hinge region, a transmembranedomain, and an intracellular T cell signaling domain. The antigen recognition domain is exposed...
A transmembrane protein is a type of integral membrane protein that spans the entirety of the cell membrane. Many transmembrane proteins function as gateways...
Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the plasma membrane of cells. They act in cell...
two distinct domains, the transmembranedomain (TMD) and the nucleotide-binding domain (NBD). The TMD, also known as membrane-spanning domain (MSD) or integral...
four transmembranedomains, with the N-terminus and the C-terminus in the cytoplasm. Claudins are small (20–24/27 kilodalton (kDa)) transmembrane proteins...
Cystic fibrosis transmembrane conductance regulator (CFTR) is a membrane protein and anion channel in vertebrates that is encoded by the CFTR gene. Geneticist...
Formate dehydrogenase consists of two transmembranedomains; three α-helices of the β-subunit and four transmembrane helices from the gamma-subunit. The...
CNNM3 (also known as cyclin M3 or Ancient conserved domain-containing protein 3) is a human transmembrane protein which is made up of 707 amino acids. Although...
ABC transporter transmembranedomain is the main transmembrane structural unit of ATP-binding cassette transporter proteins, consisting of six alpha helixes...
The F0 transmembranedomain is involved in the movement of ions across the membrane. The bacterial F0F1-ATPase consists of the soluble F1 domain and the...
11 transmembranedomains. For SERINC5 to localize itself to the plasma membrane to inhibit infectivity by viruses, an extra c-terminal transmembrane domain...
Each strand is formed from a row of transmembrane proteins embedded in both plasma membranes, with extracellular domains joining one another directly. There...
membrane-bound proteins are targeted to the secretory pathway by their first transmembranedomain, which biochemically resembles a signal sequence except that it is...
proteins which contain a transmembranedomain, as well as the non-receptor tyrosine kinases which do not possess transmembranedomains. The first RTKs to be...
CKLF like MARVEL transmembranedomain-containing 7 (i.e. CMTM7), previously termed chemokine-like factor superfamily 7 (i.e. CKLFSF7), is a protein that...
classified as a type I transmembrane protein. While this protein is not well understood by the scientific community, the transmembranedomain of SMIM14 may be...
domains namely a transmembranedomain and an extramembrane C-terminal domain. They are almost fully α-helical, with a single α-helical transmembrane domain...
variable although some of the proteins in this group have the OmpA-like transmembranedomain at the N terminus. OmpA from Escherichia coli is required for pathogenesis...
they cleave other transmembrane proteins within their transmembranedomains. About 30% of all proteins have transmembranedomains, and their regulated...
signal peptide, an N-terminal extracellular domain, a single transmembranedomain and an intracellular domain. Such proteins include meprin (a cell surface...
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