A protein superfamily is the largest grouping (clade) of proteins for which common ancestry can be inferred (see homology). Usually this common ancestry is inferred from structural alignment[1] and mechanistic similarity, even if no sequence similarity is evident.[2] Sequence homology can then be deduced even if not apparent (due to low sequence similarity). Superfamilies typically contain several protein families which show sequence similarity within each family. The term protein clan is commonly used for protease and glycosyl hydrolases superfamilies based on the MEROPS and CAZy classification systems.[2][3]
^Holm L, Rosenström P (July 2010). "Dali server: conservation mapping in 3D". Nucleic Acids Research. 38 (Web Server issue): W545–9. doi:10.1093/nar/gkq366. PMC 2896194. PMID 20457744.
^ abRawlings ND, Barrett AJ, Bateman A (January 2012). "MEROPS: the database of proteolytic enzymes, their substrates and inhibitors". Nucleic Acids Research. 40 (Database issue): D343–50. doi:10.1093/nar/gkr987. PMC 3245014. PMID 22086950.
^Henrissat B, Bairoch A (June 1996). "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal. 316 (Pt 2): 695–6. doi:10.1042/bj3160695. PMC 1217404. PMID 8687420.
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A proteinsuperfamily is the largest grouping (clade) of proteins for which common ancestry can be inferred (see homology). Usually this common ancestry...
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Look up superfamily in Wiktionary, the free dictionary. Superfamily may refer to: ProteinsuperfamilySuperfamily database Superfamily (taxonomy), a taxonomic...
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origin of this superfamily in evolution. The PROSITE pattern of this superfamily is located in a beta sheet in the central section of the protein that is conserved...
prediction Protein structure prediction software ProteinsuperfamilyProtein tandem repeats Protein family Protein subfamily Short linear motif Structural biology...
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Proteolysis Protein sequence space Protein superfamily Osborne TB (1909). "History". The Vegetable Proteins. pp. 1–6. Mulder GJ (1838). "Sur la composition...
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SUPERFAMILY is a database and search platform of structural and functional annotation for all proteins and genomes. It classifies amino acid sequences...
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refer either to the tubulin proteinsuperfamily of globular proteins, or one of the member proteins of that superfamily. α- and β-tubulins polymerize...
is a member of a BPI fold proteinsuperfamily defined by the presence of the bactericidal/permeability-increasing protein fold (BPI fold) which is formed...
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Myosins (/ˈmaɪəsɪn, -oʊ-/) are a superfamily of motor proteins best known for their roles in muscle contraction and in a wide range of other motility...
and superfamily classifications). The latest release of CATH-Gene3D (v4.3) was released in December 2020 and consists of: 500,238 structural protein domain...
SNARE proteins – "SNAP REceptors" – are a large protein family consisting of at least 24 members in yeasts, more than 60 members in mammalian cells, and...
Bile/Arsenite/Riboflavin Transporter (BART) superfamily is a superfamily of ubiquitous transport proteins. As of early 2016, the superfamily contains seven established...
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