H-Ras structure PDB 121p, surface colored by conservation in Pfam seed alignment: gold, most conserved; dark cyan, least conserved.
Identifiers
Symbol
Ras
Pfam
PF00071
InterPro
IPR013753
PROSITE
PDOC00017
SCOP2
5p21 / SCOPe / SUPFAM
CDD
cd00882
Membranome
206
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
The Ras superfamily, derived from "Rat sarcoma virus", is a protein superfamily of small GTPases.[1] Members of the superfamily are divided into families and subfamilies based on their structure, sequence and function. The five main families are Ras, Rho, Ran, Rab and Arf GTPases.[2] The Ras family itself is further divided into 6 subfamilies: Ras, Ral, Rap, Rheb, Rad and Rit. Miro is a recent contributor to the superfamily. Each subfamily shares the common core G domain, which provides essential GTPase and nucleotide exchange activity.
The surrounding sequence helps determine the functional specificity of the small GTPase, for example the 'Insert Loop', common to the Rho subfamily, specifically contributes to binding to effector proteins such as WASP.
In general, the Ras family is responsible for cell proliferation: Rho for cell morphology, Ran for nuclear transport, and Rab and Arf for vesicle transport.[3]
^Wennerberg K, Rossman KL, Der CJ (March 2005). "The Ras superfamily at a glance". J. Cell Sci. 118 (Pt 5): 843–6. doi:10.1242/jcs.01660. PMID 15731001.
^Goitre, L; Trapani, E; Trabalzini, L; Retta, SF (26 December 2013). The Ras superfamily of small GTPases: the unlocked secrets. Methods in Molecular Biology. Vol. 1120. pp. 1–18. doi:10.1007/978-1-62703-791-4_1. ISBN 978-1-62703-790-7. PMID 24470015.
^Cite error: The named reference Munemitsu was invoked but never defined (see the help page).
The Rassuperfamily, derived from "Rat sarcoma virus", is a protein superfamily of small GTPases. Members of the superfamily are divided into families...
proteins in the Rassuperfamily. Based on structure, sequence and function, the Rassuperfamily is divided into five main families, (Ras, Rho, Ran, Rab...
signals within cells (cellular signal transduction). Ras is the prototypical member of the Rassuperfamily of proteins, which are all related in three-dimensional...
member of the Rassuperfamily and is highly expressed in heart and brain tissue. DIRAS1 varies from other members of the Rassuperfamily due to amino acid...
Look up ras, Ras, RAS, rás, râs, rãs, rǡs, răs-, or Raś in Wiktionary, the free dictionary. Ras or RAS may refer to: RAS Records Real Authentic Sound,...
properties, the many Rassuperfamily small GTPases are further divided into five subfamilies with distinct functions: Ras, Rho ("Ras-homology"), Rab, Arf...
cell cycle. RHEB is a recently discovered member of the Rassuperfamily. Being a relative of Ras, the overexpression of RHEB can be seen in multiple human...
nucleophiles). Rassuperfamily Members share a common catalytic G domain of a 6-strand β sheet surrounded by 5 α-helices. RSH superfamily Members share...
a small G protein in the Ras subfamily of the Rassuperfamily of small GTPases. Once bound to Guanosine triphosphate, H-Ras will activate a Raf kinase...
sleeping-bag manufacturer Rab (G-protein), a cellular protein in the Rassuperfamily Rab battalion, a World War II unit of Jewish survivors of Rab concentration...
GTPases, are part of a larger family of related proteins known as the Rassuperfamily, a family of proteins involved in the regulation and timing of cell...
many downstream targets. The most well-known GTPases comprise the Rassuperfamily and are involved in essential cell processes such as cell differentiation...
of small (~21 kDa) signaling G proteins, and is a subfamily of the Rassuperfamily. The members of the Rho GTPase family have been shown to regulate many...
and gamma (γ) subunits. "Small" G proteins (20-25kDa) belong to the Rassuperfamily of small GTPases. These proteins are homologous to the alpha (α) subunit...
(ARFs) are members of the ARF family of GTP-binding proteins of the Rassuperfamily. ARF family proteins are ubiquitous in eukaryotic cells, and six highly...
encodes a small GTP-binding protein and is a member of the Rassuperfamily. "RAB7, member RAS oncogene family-like 1". Retrieved 2011-12-06. Shimizu, F...
(1952–2015), British cell biologist, best known for studying the role of Rassuperfamily proteins in cancer Allan Hall (footballer) (1908–1983), English footballer...
RAS-like, estrogen-regulated, growth inhibitor is a protein in humans that is encoded by the RERG gene. RERG, a member of the RASsuperfamily of GTPases...
CJ (1995). "Guanine nucleotide exchange factors: Activators of the Rassuperfamily of proteins". BioEssays. 17 (5): 395–404. doi:10.1002/bies.950170507...
protein structure, and the most well studied is the Rassuperfamily, of which Rap1 is a member. Whereas Ras is known for its role in cell proliferation and...
perturbations at Rasgrf1 in mouse". Ithaca, N.Y.: Cornell University. (See Rassuperfamily and Ras-GRF1.) Zimmer, Carl (March 10, 2014). "Please Welcome Nadia Drake...
of a protein. Farnesyltransferase's targets include members of the Rassuperfamily of small GTP-binding proteins critical to cell cycle progression. For...
that stimulate their intrinsic GTPase activity. All GTPases of the Rassuperfamily have in common the presence of six conserved motifs involved in GTP/GDP...
and Spindly. The light intermediate chain, which is a member of the Rassuperfamily, mediates the attachment of several cargo adaptors to the dynein motor...
Global Information