Protein subfamily is a level of protein classification, based on their close evolutionary relationship. It is below the larger levels of protein superfamily and protein family.[1]
Proteins typically share greater sequence and function similarities with other subfamily members than they do with members of their wider family.[1][2] For example, in the Structural Classification of Proteins database classification system, members of a subfamily share the same interaction interfaces and interaction partners.[3] These are stricter criteria than for a family, where members have similar structures, but may be more distantly related and so have different interfaces. Subfamilies are assigned by a variety of methods, including sequence similarity,[4] motifs linked to function,[5] or phylogenetic clade.[6][7] There is no exact and consistent distinction between a subfamily and a family. The same group of proteins may sometimes be described as a family or a subfamily, depending on the context.
^ ab"What are protein families?". EMBL-EBI Train online. 2011-11-18. Retrieved 2018-03-08.
^Das, Sayoni; Orengo, Christine A. (2016). "Protein function annotation using protein domain family resources" (PDF). Methods. 93: 24–34. doi:10.1016/j.ymeth.2015.09.029. PMID 26434392.
^Rausell, Antonio; Juan, David; Pazos, Florencio; Valencia, Alfonso (2010-02-02). "Protein interactions and ligand binding: From protein subfamilies to functional specificity". Proceedings of the National Academy of Sciences. 107 (5): 1995–2000. Bibcode:2010PNAS..107.1995R. doi:10.1073/pnas.0908044107. PMC 2808218. PMID 20133844.
^Eisen, Jonathan A.; Sweder, Kevin S.; Hanawalt, Philip C. (1995-07-25). "Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions". Nucleic Acids Research. 23 (14): 2715–2723. doi:10.1093/nar/23.14.2715. ISSN 0305-1048. PMC 307096. PMID 7651832.
^Wicker, Nicolas; Perrin, Guy René; Thierry, Jean Claude; Poch, Olivier (2001-08-01). "Secator: A Program for Inferring Protein Subfamilies from Phylogenetic Trees". Molecular Biology and Evolution. 18 (8): 1435–1441. doi:10.1093/oxfordjournals.molbev.a003929. ISSN 0737-4038. PMID 11470834.
^Mi, Huaiyu; Poudel, Sagar; Muruganujan, Anushya; Casagrande, John T.; Thomas, Paul D. (2016-01-04). "PANTHER version 10: expanded protein families and functions, and analysis tools". Nucleic Acids Research. 44 (D1): D336–D342. doi:10.1093/nar/gkv1194. ISSN 0305-1048. PMC 4702852. PMID 26578592.
Proteinsubfamily is a level of protein classification, based on their close evolutionary relationship. It is below the larger levels of protein superfamily...
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Protein structure prediction software Protein superfamily Protein tandem repeats Protein family Proteinsubfamily Short linear motif Structural biology...
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INO80 subfamily of chromatin remodeling complexes are ATPases, and includes the INO80 and SWR1 complexes. One of the main roles of the INO80 subfamily is...
C‑type lectin 1 (Dectin1) subfamily, and DC immunoreceptor (DCIR) subfamily. Furthermore, Dectin subfamily and DCIR subfamily consist of some members as...
Olfactory receptor 6A2 is a protein that in humans is encoded by the OR6A2 gene. It is Class II (tetrapod-specific) olfactory receptor and a rhodopsin-like...
gene products organized by biological function, using curated protein family and subfamily classification". Nucleic Acids Research. 31 (1): 334–341. doi:10...
example the 'Insert Loop', common to the Rho subfamily, specifically contributes to binding to effector proteins such as WASP. In general, the Ras family...
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Alphaherpesvirinae subfamily, which includes herpes simplex viruses 1 and 2 and varicella-zoster virus, and the Gammaherpesvirinae subfamily, which includes...
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family member 3 AFTPH: encoding protein Aftiphilin ALMS1: Alstrom syndrome 1 ABCG5 and ABCG8: ATP-binding cassette, subfamily A, members 5 and 8 ASXL2: Additional...
respiratory tract infections. The family has four subfamilies, 17 genera, three of which are unassigned to a subfamily, and 78 species. Virions are enveloped and...
genes identified in the human genome, 58 encode receptor tyrosine kinase proteins. Receptor tyrosine kinases have been shown not only to be key regulators...
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