MAP1LC3B information

MAP1LC3B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V49, 2LUE, 2ZJD, 3VTU, 3VTV, 3VTW, 3WAO, 3X0W, 4WAA, 5D94, 5DCN
Identifiers
Aliases	MAP1LC3B, ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a, microtubule associated protein 1 light chain 3 beta
External IDs	OMIM: 609604 MGI: 1914693 HomoloGene: 69359 GeneCards: MAP1LC3B
Gene location (Human)
Chr.	Chromosome 16 (human)
End	87,404,779 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	122,325,499 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; frontal pole; ; postcentral gyrus; ; external globus pallidus; ; pons; ; middle frontal gyrus; ; dorsolateral prefrontal cortex; ; cingulate gyrus; ; hypothalamus; ; gastrocnemius muscle;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; medial vestibular nucleus; ; morula; ; pontine nuclei; ; iris; ; ciliary body; ; dorsal tegmental nucleus; ; ventral tegmental area; ; lateral geniculate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin protein ligase binding; microtubule binding;
Cellular component	cytoplasm; organelle membrane; membrane; intracellular anatomical structure; mitochondrion; axoneme; microtubule; cytoskeleton; cytoplasmic vesicle; endomembrane system; autophagosome membrane; cytosol; autophagosome; autolysosome;
Biological process	autophagy of mitochondrion; autophagosome assembly; autophagy; cellular response to nitrogen starvation; cellular response to starvation; macroautophagy; autophagosome maturation; positive regulation of mucus secretion;
	Sources:Amigo / QuickGO
Orthologs
	81631
	67443
	ENSG00000140941
	ENSMUSG00000031812
	Q9GZQ8
	Q9CQV6
	NM_022818
	NM_026160; NM_001364358
	NP_073729
	NP_080436; NP_001351287
	Wikidata
View/Edit Human	View/Edit Mouse

Microtubule-associated proteins 1A/1B light chain 3B (hereafter referred to as LC3) is a protein that in humans is encoded by the MAP1LC3B gene.^[5] LC3 is a central protein in the autophagy pathway where it functions in autophagy substrate selection and autophagosome biogenesis. LC3 is the most widely used marker of autophagosomes.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140941 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031812 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MAP1LC3B microtubule-associated protein 1 light chain 3 beta".
^ Cite error: The named reference Klionsky_2016 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140941 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031812 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MAP1LC3B microtubule-associated protein 1 light chain 3 beta".

[Klionsky_2016-6] Cite error: The named reference Klionsky_2016 was invoked but never defined (see the help page).

MAP1LC3B information

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