The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic kingdoms, including yeasts and some plants. Three members of the family have been studied in detail: Cdc42, Rac1, and RhoA. All G proteins are "molecular switches", and Rho proteins play a role in organelle development, cytoskeletal dynamics, cell movement, and other common cellular functions.[1][2][3][4][5]
^Cite error: The named reference Boureux was invoked but never defined (see the help page).
^Bustelo XR, Sauzeau V, Berenjeno IM (2007). "GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo". BioEssays. 29 (4): 356–370. doi:10.1002/bies.20558. PMC 1971132. PMID 17373658.
^Ridley, Anne J (2015). "Rho GTPase signalling in cell migration". Current Opinion in Cell Biology. 36: 103–112. doi:10.1016/j.ceb.2015.08.005. PMC 4728192. PMID 26363959.
^Ridley, Anne Jacqueline (2016). "Anne Ridley: Networking with Rho GTPases". Trends in Cell Biology. 26 (7): 465–466. doi:10.1016/j.tcb.2016.04.005. ISSN 0962-8924. PMID 27166090. (subscription required)
^Heasman, Sarah J.; Ridley, Anne J. (2008). "Mammalian Rho GTPases: new insights into their functions from in vivo studies". Nature Reviews Molecular Cell Biology. 9 (9): 690–701. doi:10.1038/nrm2476. PMID 18719708. (subscription required)
and 22 Related for: Rho family of GTPases information
RhofamilyofGTPases is a familyof small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the RhoGTPase family...
up Rho or rho in Wiktionary, the free dictionary. RhoGTPase may refer to: Any member of the RhofamilyofGTPases The members of the Rhofamilyof GTPases...
Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the RhofamilyofGTPases that in humans is encoded...
confusion with the Latin letter p In molecular biology to represent the RhofamilyofGTPases, important for cytoskeletal dynamic regulation. In ecology to represent...
specifically a GTPase), and is a member of the Rac subfamily of the familyRhofamilyofGTPases. It is encoded by the gene RHOC. It is prenylated at its...
(G-actin) or filamentous (F-actin) forms. The role ofRhofamilyofGTPases and its effects in the stability of actin and spine motility has important implications...
domain common to many GTPases. GTPases function as molecular switches or timers in many fundamental cellular processes. Examples of these roles include:...
subfamily of the familyRhofamilyofGTPases. It is encoded by the gene RHOD. It binds GTP and is involved in endosome dynamics and reorganization of the actin...
signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the RhofamilyofGTPases. It is encoded by the gene RND1. It contributes...
regulate small GTPases in the Rho family. Rho small GTPases are inactive when bound to GDP but active when bound to GTP; RhoGEF domains in proteins are able...
The RhoBTB family is a subgroup of the Rhofamilyof small GTPases. They are a highly divergent class and are all characterized by an N-terminal Rho-related...
a GTPase), and is a member of the Rnd subgroup of the RhofamilyofGTPases. It is encoded by the gene RND3. Like other members of the Rhofamilyof Ras-related...
(GDP). The best-known members are the Ras GTPases and hence they are sometimes called Ras subfamily GTPases. A typical G-protein is active when bound...
familyof proteins is homologous to the Ras GTPases and is also called the Ras superfamily GTPases. In order to associate with the inner leaflet of the...
signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the RhofamilyofGTPases. It is encoded by the gene RND2. It contributes...
a type of protein in the RhofamilyofGTPases heals wounds by contraction, much like a draw-string being pulled to close a bag. "Definition of DRAWSTRING"...
specifically a GTPase), and is a member of the RhofamilyofGTPases. Further reading: RhofamilyofGTPases Ridley A. (2006). "RhoGTPases and actin dynamics...
locomotion. Activation of the RhofamilyofGTPases, particularly Cdc42 and their downstream intermediates, results in the polymerization of actin fibers by...
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