De novo protein synthesis theory of memory formation information
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The de novo protein synthesis theory of memory formation is a hypothesis about the formation of the physical correlates of memory in the brain. It is widely accepted that the physiological correlates for memories are stored at the synapse between various neurons. The relative strength of various synapses in a network of neurons form the memory trace, or ‘engram,’ though the processes that support this finding are less thoroughly understood. The de novo protein synthesis theory states that the production of proteins is required to initiate and potentially maintain these plastic changes within the brain. It has much support within the neuroscience community, but some critics claim that memories can be made independent of protein synthesis.
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fear memory, when reactivated, enters a changeable state that requires denovoproteinsynthesis for new consolidation, i.e., re-consolidation of the old...
long-term memory. By 2015 it had become clear that long-term memory requires gene transcription activation and denovoproteinsynthesis. Long-term memory formation...
cell survival, proteinsynthesis, autophagy, and transcription. As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes...
Kim J, Park HY (July 2022). "Real-time visualization of mRNA synthesis during memoryformation in live mice". Proc Natl Acad Sci U S A. 119 (27): e2117076119...
including denovo sequencing directly from tandem mass spectra and database search methods that use existing protein sequence databases. Many versions of shotgun...
figure. The thousands of CpG sites being demethylated during memoryformation depend on ROS in an initial step. The altered protein expression in neurons...
and interferons that have anti-viral effects, such as shutting down proteinsynthesis in the host cell. Growth factors and cytotoxic factors may also be...
long-term memory. By 2015 it had become clear that long-term memory requires gene transcription activation and denovoproteinsynthesis. Long-term memory formation...
of a protein scaffold on the inner edge of the nucleus called the nuclear lamina that helps organize nuclear processes such as RNA and DNA synthesis.[citation...
function of a protein. He published this theory in 1958. RNA sequencing was one of the earliest forms of nucleotide sequencing. The major landmark of RNA sequencing...
structure of a polyribonucleic acid sequence based on its sequence and environment? Protein design: Is it possible to design highly active enzymes denovo for...
lysine towards the synthesisof stable seed storage proteins, and subsequently, increase the nutritional value of the consumable component of crops. While genetic...
this illusion in a variety of manners, including the up-regulation of niacin receptors and up-regulation ofdenovosynthesisof NAD from tryptophan via...
elements have been proposed. ACLAME (The CLAssification of Mobile genetic Elements) database Denovo gene birth Exon shuffling Gene fusion Gene duplication...
new phase of matter, named a "light-matter hybrid", which may reshape understanding of how light interacts with matter. A study ofproteins in cerebrospinal...
that control proteinsynthesis in neuronal cells in response to cell needs, activity and adhesion of neuronal cells, synapse formation and remodeling...
cognition has made it a target of study for many neurological disorders, including autism spectrum disorder (ASD). Denovo deletions in the HNMT gene have...
"Targeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction ofdenovo CTL responses...
H.; Yeh, C. F.; Yao, C. J.; Li, S. H. (2013). "The DeNovo Assembly of Mitochondrial Genomes of the Extinct Passenger Pigeon (Ectopistes migratorius)...
Shively, K. M.; et al. (2015). "Denovo mutations in NALCN cause a syndrome characterized by congenital contractures of the limbs and face, hypotonia,...
potential origin of life from a RNA world – synergistic formationof peptides and ever-longer RNAs or peptide-decorated RNA, leading to a protein world. A study...
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