The NMR structure of a UBA domain from the protein ubiquilin-1 (top, cyan) bound to ubiquitin (bottom, orange), illustrating the three-helix bundle structure of the UBA domain. Isoleucine 44, the center of a hydrophobic patch on the ubiquitin surface that interacts with a number of ubiquitin-binding domains, is highlighted in blue. Rendered from PDB: 2JY6.[1]
Identifiers
Symbol
UBA
Pfam
PF00627
Pfam clan
CL0214
InterPro
IPR015940
PROSITE
PDOC50030
SCOP2
1efu / SCOPe / SUPFAM
CDD
cd00194
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Not to be confused with Ubiquitin-activating enzyme, also sometimes abbreviated UBA.
Ubiquitin-associated (UBA) domains are protein domains that non-covalently interact with ubiquitin through protein-protein interactions. Ubiquitin is a small protein that is covalently linked to other proteins as part of intracellular signaling pathways, often as a signal for protein degradation. UBA domains are among the most common ubiquitin-binding domains.[2][3]
^Zhang D, Raasi S, Fushman D (March 2008). "Affinity makes the difference: nonselective interaction of the UBA domain of Ubiquilin-1 with monomeric ubiquitin and polyubiquitin chains". Journal of Molecular Biology. 377 (1): 162–80. doi:10.1016/j.jmb.2007.12.029. PMC 2323583. PMID 18241885.
^Dikic I, Wakatsuki S, Walters KJ (October 2009). "Ubiquitin-binding domains - from structures to functions". Nature Reviews. Molecular Cell Biology. 10 (10): 659–71. doi:10.1038/nrm2767. PMC 7359374. PMID 19773779.
^Husnjak K, Dikic I (7 July 2012). "Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions". Annual Review of Biochemistry. 81 (1): 291–322. doi:10.1146/annurev-biochem-051810-094654. PMID 22482907.
and 23 Related for: UBA protein domain information
Ubiquitin-associated (UBA) domains are proteindomains that non-covalently interact with ubiquitin through protein-protein interactions. Ubiquitin is a small protein that...
In molecular biology, the UBX proteindomain is found in ubiquitin-regulatory proteins, which are members of the ubiquitination pathway, as well as a number...
name for the protein NXF1 is TAP. In particular this entry focuses on the C-terminal domain, which also contains the UBA (proteindomain). This entry...
Ubiquitin-associated domain-containing protein 1 is a protein that in humans is encoded by the UBAC1 gene. GRCh38: Ensembl release 89: ENSG00000130560...
Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ubiquitously. It was discovered in...
UBXD8 is a protein in the Ubiquitin regulatory X (UBX) domain-containing protein family. The UBX domain contains many eukaryotic proteins that have similarities...
(2004-10-26). "Structural and functional studies of mutations affecting the UBAdomain of SQSTM1 (p62) which cause Paget's disease of bone". Biochemical Society...
Ubiquitin-associated protein 1 is a protein that in humans is encoded by the UBAP1 gene. This gene is a member of the ubiquitin-associated domain (UBA) family, whose...
Ubiquitin-receptor proteins have an N-terminal ubiquitin-like (UBL) domain and one or more ubiquitin-associated (UBA) domains. The UBL domains are recognized...
1016/S0962-8924(00)01834-1. PMID 10998601. "Entrez Gene: HUWE1 HECT, UBA and WWE domain containing 1". Giles AC, Grill B (April 2020). "Roles of the HUWE1...
full-length protein encoded by this gene contains a UBA-domain (ubiquitin associated domain), which is a motif found in several proteins having connections...
Polyubiquitin-C is a protein encoded by the UBC gene in humans. Polyubiquitin-C is one of the sources of ubiquitin, along with UBB, UBA52, and RPS27A...
Ubiquitin-associated and SH3 domain-containing protein A is a protein that in humans is encoded by the UBASH3A gene. GRCh38: Ensembl release 89: ENSG00000160185...
three amino-terminal BIR domains followed by one UBAdomain and finally one RING domain. Between the BIR-1 and BIR-2 domains, there is a linker-BIR-2...
Liu CF, Chen IS, Feigon J (1998). "Structure of a human DNA repair proteinUBAdomain that interacts with HIV-1 Vpr". Nat. Struct. Biol. 5 (12): 1042–1047...
Knebel A, Arthur JS, Cuenda A, Cohen P (December 2004). "A novel UBA and UBX domainprotein that binds polyubiquitin and VCP and is a substrate for SAPKs"...
intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded...
Ubiquitin-like modifier-activating enzyme 5 is a protein that in humans is encoded by the UBA5 gene. This gene encodes a member of the E1-like activating...
Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene. The protein encoded by this gene was originally identified as...
ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived...
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