The PDZ domain is a common structural domain of 80-90 amino-acids found in the signaling proteins of bacteria, yeast, plants, viruses[1] and animals.[2] Proteins containing PDZ domains play a key role in anchoring receptor proteins in the membrane to cytoskeletal components. Proteins with these domains help hold together and organize signaling complexes at cellular membranes. These domains play a key role in the formation and function of signal transduction complexes.[3] PDZ domains also play a highly significant role in the anchoring of cell surface receptors (such as Cftr and FZD7) to the actin cytoskeleton via mediators like NHERF and ezrin.[4]
PDZ is an initialism combining the first letters of the first three proteins discovered to share the domain — post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1).[5] PDZ domains have previously been referred to as DHR (Dlg homologous region)[6] or GLGF (glycine-leucine-glycine-phenylalanine) domains.[7]
In general PDZ domains bind to a short region of the C-terminus of other specific proteins. These short regions bind to the PDZ domain by beta sheet augmentation. This means that the beta sheet in the PDZ domain is extended by the addition of a further beta strand from the tail of the binding partner protein.[8] The C-terminal carboxylate group is bound by a nest (protein structural motif) in the PDZ domain, i.e. a PDZ-binding motif.
^Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L (August 2008). "The HTLV-1 Tax interactome". Retrovirology. 5: 76. doi:10.1186/1742-4690-5-76. PMC 2533353. PMID 18702816.
^Ponting CP (February 1997). "Evidence for PDZ domains in bacteria, yeast, and plants". Protein Science. 6 (2): 464–8. doi:10.1002/pro.5560060225. PMC 2143646. PMID 9041651.
^Cite error: The named reference pmid20509869 was invoked but never defined (see the help page).
^Li J, Callaway DJ, Bu Z (September 2009). "Ezrin induces long-range interdomain allostery in the scaffolding protein NHERF1". Journal of Molecular Biology. 392 (1): 166–80. doi:10.1016/j.jmb.2009.07.005. PMC 2756645. PMID 19591839.
^Kennedy MB (September 1995). "Origin of PDZ (DHR, GLGF) domains". Trends in Biochemical Sciences. 20 (9): 350. doi:10.1016/S0968-0004(00)89074-X. PMID 7482701.
^Ponting CP, Phillips C (March 1995). "DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins". Trends in Biochemical Sciences. 20 (3): 102–3. doi:10.1016/S0968-0004(00)88973-2. PMID 7535955.
^Cho KO, Hunt CA, Kennedy MB (November 1992). "The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein". Neuron. 9 (5): 929–42. doi:10.1016/0896-6273(92)90245-9. PMID 1419001. S2CID 28528759.
^Cowburn D (December 1997). "Peptide recognition by PTB and PDZ domains". Current Opinion in Structural Biology. 7 (6): 835–8. doi:10.1016/S0959-440X(97)80155-8. PMID 9434904.
The PDZdomain is a common structural domain of 80-90 amino-acids found in the signaling proteins of bacteria, yeast, plants, viruses and animals. Proteins...
with the PDZdomain. The only conserved residues in these structures are those involved in the recognition of the carboxy terminal. PDZdomains are quite...
proline-heavy region between the DIX and PDZdomains, and a largely basic region between the DIX and PDZdomains that has conserved serine and threonine...
for the Xbox 360 in 2005 PDZdomain, a protein domain This disambiguation page lists articles associated with the title PDZ. If an internal link led you...
PDZdomain containing 9 is a protein that in humans is encoded by the PDZD9 gene. ENSG00000155714 GRCh38: Ensembl release 89: ENSG00000284316, ENSG00000155714...
MAGUK-family of PDZdomain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZdomains, an SH3 domain, and a guanylate...
FERM and PDZdomain containing 2 is a protein that in humans is encoded by the FRMPD2 gene. This gene encodes a peripheral membrane protein and is located...
for their stability and targeting. This domain contains PDZ-binding motif, that facilitate to bind them to the PDZ membrane proteins, like a ZO-1, ZO-2,...
FERM and PDZdomain containing 4 is a protein that in humans is encoded by the FRMPD4 gene. This gene encodes a multi-domain (WW, PDZ, FERM) containing...
contain PDZ-binding domains, but which PDZdomain they bind to differs. For example, GluA1 binds to SAP97 through SAP97's class I PDZdomain, while GluA2...
protein FERM and PDZdomain containing 3 FRMPD4: encoding protein FERM and PDZdomain containing 4 FUNDC1: encoding protein FUN14 domain containing 1 FUNDC2:...
LIM domain binding 3 (LDB3), also known as Z-band alternatively spliced PDZ-motif (ZASP), is a protein which in humans is encoded by the LDB3 gene. ZASP...
Vestweber D (Sep 2000). "Junctional adhesion molecule interacts with the PDZdomain-containing proteins AF-6 and ZO-1". The Journal of Biological Chemistry...
both their cytoplasmic and extracellular domains through interaction with scaffolding that contains a PDZdomain and adjacent cell's receptors, respectively...
One of the downstream targets of TGF β signaling, GIPC, binds to its PDZdomain, which prevents its proteosomal degradation, which subsequently increases...
GIPC PDZdomain containing family, member 1 (GIPC1) is a protein that in humans is encoded by the GIPC1 gene. GIPC was originally identified as it binds...
Multiple PDZdomain protein is a protein that in humans is encoded by the MPDZ gene. MPDZ has been shown to interact with: 5-HT2C receptor, CD117, and...
Membrane-associated guanylate kinase, WW and PDZdomain-containing protein 1 is an enzyme that in humans is encoded by the MAGI1 gene. The protein encoded...
N-terminal domain, three PDZdomains, an SH3 domain, hook domain, I3 domain, and finally an inactive guanylate kinase (GK) domain. Each of these domains has...
(September 1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZdomain protein". The Journal of Neuroscience. 19 (18): 7770–7780. doi:10.1523/JNEUROSCI...
carboxyl terminal of the protein is anchored to the cytoskeleton by a PDZdomain interaction. The majority of CFTR in lung passages is produced by rare...
Global Information