Global InformationYadA bacterial adhesin protein domain information
| YadA bacterial adhesin protein domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 The beta barrel structure found in the C-terminus of the bacterial adhesin protein domain, YadA [1] | |||||||||
| Identifiers | |||||||||
| Symbol | YadA | ||||||||
| Pfam | PF03895 | ||||||||
| Pfam clan | CL0327 | ||||||||
| InterPro | IPR005594 | ||||||||
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In molecular biology, YadA is a protein domain which is short for Yersinia adhesin A. These proteins have strong sequence and structural homology, particularly at their C-terminal end. The function is to promote their pathogenicity and virulence in host cells, though cell adhesion. YadA is found in three pathogenic species of Yersinia, Y. pestis, Y. pseudotuberculosis, and Y. enterocolitica. The YadA domain is encoded for by a virulence plasmid in Yersinia, which encodes a type-III secretion (T3S) system consisting of the Ysc injectisome and the Yop effectors.[1]
- ^ Casutt-Meyer S, Renzi F, Schmaler M, Jann NJ, Amstutz M, Cornelis GR (2010). "Oligomeric coiled-coil adhesin YadA is a double-edged sword". PLOS ONE. 5 (12): e15159. Bibcode:2010PLoSO...515159C. doi:10.1371/journal.pone.0015159. PMC 2999546. PMID 21170337.