Prolactin receptor information

The prolactin receptor (PRLR) is a type I cytokine receptor encoded in humans by the PRLR gene on chromosome 5p13-14. It is the receptor for prolactin (PRL)...

autocrine, and paracrine manners through the prolactin receptor and numerous cytokine receptors. Pituitary prolactin secretion is regulated by endocrine neurons...

respectively. Prolactin inhibitors are mainly used to treat hyperprolactinemia (high prolactin levels). Agonists of the dopamine D2 receptor such as bromocriptine...

agonist of the prolactin receptor and a weak agonist of the growth hormone receptor. hPL has been found to bind to the prolactin receptor with equal affinity...

like gastroparesis (delayed gastric emptying). It raises the level of prolactin in the human body and is used off label to induce and promote breast milk...

system in such a way to increase the production of prolactin; specifically, by blocking the D2 receptor. There is some evidence to suggest that mothers who...

increased prolactin release. Prolactin secretion in the pituitary is normally suppressed by the brain chemical dopamine, which binds to dopamine receptors. Drugs...

pathways activated by the EpoR are common to many other receptors; replacing EpoR with prolactin receptor supports erythroid survival and differentiation in...

among others, is a dopaminergic medication used in the treatment of high prolactin levels, prolactinomas, Parkinson's disease, and for other indications...

A (2004). "Endogenous human prolactin and not exogenous human prolactin induces estrogen receptor α and prolactin receptor expression and increases estrogen...

functional interaction with the GH receptor. It appears that, in structure, GH is evolutionarily homologous to prolactin and chorionic somatomammotropin...

were identified as prolactin-like molecules that can bind to prolactin receptor with high affinity and mimic the actions of prolactin. These hormones can...

deficiency in the serum levels of the hypothalamic-pituitary hormone prolactin. Hypoprolactinemia is associated with ovarian dysfunction in women, and...

Parkinson's disease and ability to suppress prolactin levels, while interactions with serotonin receptors are thought to be principally involved in its...

v t e Galactagogues Prolactin receptor agonists Growth hormone/somatotropin Human placental lactogen Prolactin Prolactin releasers Others Breast development...

S2CID 37973363. Khong HK, Kuah MK, Jaya-Ram A, Shu-Chien AC (May 2009). "Prolactin receptor mRNA is upregulated in discus fish (Symphysodon aequifasciata) skin...

Erythropoietin receptor GM-CSF receptor G-CSF receptor Thrombopoietin receptor Growth hormone receptor Prolactin receptor Leptin receptor Oncostatin M receptor Leukemia...

the ergoline group which is used as a prolactin inhibitor in the treatment of hyperprolactinemia (high prolactin levels) and to suppress lactation. Metergoline...

D2–ghrelin receptor D2sh–TAAR1 The D2 receptor has been shown to form hetorodimers in vitro (and possibly in vivo) with DRD3, DRD5, and 5-HT2A. Prolactin modulator...

secretion of oxytocin and to increase the expression of its receptor, the oxytocin receptor, in the brain. In women, a single dose of estradiol has been...

D2 receptors with nanomolar affinity (Ki = 28.8 nM), where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/5-HT4 receptor agonist...

is a serotonin receptor antagonist and dopamine receptor agonist of the ergoline family. It is approved for and used as a prolactin inhibitor in the...

v t e Galactagogues Prolactin receptor agonists Growth hormone/somatotropin Human placental lactogen Prolactin Prolactin releasers Others Breast development...