Product inhibition is a type of enzyme inhibition where the product of an enzyme reaction inhibits its production.[1] Cells utilize product inhibition to regulate of metabolism as a form of negative feedback controlling metabolic pathways.[2] Product inhibition is also an important topic in biotechnology, as overcoming this effect can increase the yield of a product, such as an antibiotic.[3] Product inhibition can be competitive, non-competitive or uncompetitive.
^Walter, Charles; Frieden, Earl (1963). "The Prevalence and Significance of the Product Inhibition of Enzymes". In Nord, F.F. (ed.). Advances in Enzymology and Related Subjects of Biochemistry. Vol. 25. pp. 167–274. doi:10.1002/9780470122709.ch4. ISBN 978-0-470-12270-9. PMID 14149677.
^Hutson, NJ; Kerbey, AL; Randle, PJ; Sugden, PH (1979). "Regulation of pyruvate dehydrogenase by insulin action". Progress in Clinical and Biological Research. 31: 707–719. PMID 231784. NAID 10010916605.
^Schügerl, Karl; Hubbuch, Jürgen (June 2005). "Integrated bioprocesses". Current Opinion in Microbiology. 8 (3): 294–300. doi:10.1016/j.mib.2005.01.002. PMID 15939352.
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Productinhibition is a type of enzyme inhibition where the product of an enzyme reaction inhibits its production. Cells utilize productinhibition to...
becomes occupied, inhibiting the enzyme. Productinhibition (either the enzyme's own product, or a product to an enzyme downstream in its metabolic pathway)...
Substrate inhibition in bioreactors occurs when the concentration of substrate (such as glucose, salts, or phenols) exceeds the optimal parameters and...
The regulation of the citric acid cycle is largely determined by productinhibition and substrate availability. If the cycle were permitted to run unchecked...
bacteria have not grown enough to be visible. This is called a zone of inhibition. The susceptibility of the bacterial isolate to each antibiotic can then...
Competitive inhibition is interruption of a chemical pathway owing to one chemical substance inhibiting the effect of another by competing with it for...
neurons), as well as providing an alternative for migraine prophylaxis. Inhibition of both MAO-A and MAO-B is used in the treatment of clinical depression...
Uncompetitive inhibition (which Laidler and Bunting preferred to call anti-competitive inhibition, but this term has not been widely adopted) is a type...
This final step also requires ATP. This pathway is suppressed by end-productinhibition, meaning that CoA is a competitive inhibitor of pantothenate kinase...
oxaloacetate. Citrate inhibits the reaction and is an example of productinhibition. The inhibition of citrate synthase by acetyl-CoA analogues has also been...
assumption about the mechanism only involving no intermediate or productinhibition, and there is no allostericity or cooperativity). The first assumption...
Regulated by Feedback Inhibition. Nierlich DP, Magasanik B (1965). "Regulation of purine ribonucleotide synthesis by end productinhibition. the effect of adenine...
Unfortunately, this catalyst has a problem with productinhibition. To by pass that problem, the product of the cyclization reaction could be reacted with...
a bifunctional enzyme called COASY. This pathway is regulated by productinhibition. CoA is a competitive inhibitor for Pantothenate Kinase, which normally...
kinases in the nucleus. Allosteric inhibition and activation by metabolites: In particular end-productinhibition of regulated enzymes by metabolites...
synthesis of DNA and RNA. They achieve GPAT inhibition through a form of negative feedback called productinhibition. Because actively replicating cells (such...
no product terms in the rate equation which can be problematic for those wishing to build metabolic models since there are no productinhibition terms...
exchanged and the overall rate will depend on the subtype. To reduce productinhibition of photosynthetic enzymes (for instance PECP) concentration gradients...
triamcinolone acetonide can produce endocrine side effects like ovulation inhibition and menstrual irregularities. Triamcinolone acetonide, also known as...
domains stabilizing the open structure and preventing catalysis. Strong productinhibition has been observed with a Ki of 0.5 μM. Though the exact catalytic...
the purine ring of the substrate. Competitive inhibition has been observed for ADA, where the product inosine acts at the competitive inhibitor to enzymatic...
natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include...
enzyme so that Vmax is reduced. In contrast to competitive inhibition, non-competitive inhibition cannot be overcome with high substrate concentration.: 76–78 ...
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