Ethanol (C 2H 5OH) serves as a competitive inhibitor to methanol (CH 3OH) and ethylene glycol ((CH2OH)2) for the enzyme alcohol dehydrogenase in the liver when present in large amounts. For this reason, ethanol is sometimes used as a means to treat or prevent toxicity following accidental ingestion of these chemicals.
Competitive inhibition is interruption of a chemical pathway owing to one chemical substance inhibiting the effect of another by competing with it for binding or bonding. Any metabolic or chemical messenger system can potentially be affected by this principle, but several classes of competitive inhibition are especially important in biochemistry and medicine, including the competitive form of enzyme inhibition, the competitive form of receptor antagonism, the competitive form of antimetabolite activity, and the competitive form of poisoning (which can include any of the aforementioned types).
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Competitiveinhibition is interruption of a chemical pathway owing to one chemical substance inhibiting the effect of another by competing with it for...
as a non-competitive inhibitor. Non-competitiveinhibition is sometimes thought of as a special case of mixed inhibition. In mixed inhibition, the inhibitor...
longer bind substrate (kinetically indistinguishable from competitive orthosteric inhibition) or alternatively stabilise binding of substrate to the enzyme...
substrate inhibition. Two equations listed below that are referred to as non-competitive substrate inhibition and competitive substrate inhibition models...
works. This can be competitiveinhibition, uncompetitive inhibition, non-competitiveinhibition or partially competitiveinhibition. If the molecule induces...
duration of inhibition of agonist activity. The affinity of an antagonist can be determined experimentally using Schild regression or for competitive antagonists...
Uncompetitive inhibition (which Laidler and Bunting preferred to call anti-competitiveinhibition, but this term has not been widely adopted) is a type...
first to study enzyme inhibition, and to classify inhibition types as competitive or non-competitive. In competitiveinhibition the apparent value of...
the enzyme so that Vmax is reduced. In contrast to competitiveinhibition, non-competitiveinhibition cannot be overcome with high substrate concentration...
acceptance. The receptor occupancy model, which describes agonist and competitive antagonists, was built on the work of Langley, Hill, and Clark. The occupancy...
inhibitors. They work by modifying the immune system via cytokine activity inhibition. Cytokines play key roles in controlling cell growth and the immune response...
to benzodiazepines (particularly in cases of overdose), through competitiveinhibition. It was first characterized in 1981, and was first marketed in 1987...
inflammatory effects of AA's eicosanoids in three ways: displacement, competitiveinhibition, and direct counteraction. Dietary ω-3 decreases tissue concentrations...
chlorzoxazone may reduce the liver toxicity of acetaminophen by competitiveinhibition. It is available as a generic medication. Like metaxalone, its mechanism...
proteins that have been reported to demonstrate both non-competitive and competitiveinhibition of PGs. The active site of PG interacts with a pocket containing...
hydrolyzable by urease; it thus disrupts the bacteria's metabolism through competitiveinhibition. In 1983 the US Food and Drug Administration approved acetohydroxamic...
interior may act to transmit such signals. ASD database Anharmonicity Competitiveinhibition Cooperative binding Enzyme kinetics Protein dynamics Receptor theory...
(depolarisation block), i.e. stimulation then block stimulation Competitiveinhibition of nicotinic receptor Neuromuscular blockers act at neuromuscular...
Mechanisms other than direct hepatocyte injury includes competitiveinhibition by drug metabolites, such as troglitazone metabolites, that outcompete...
inhibitor can have drastic effects on cognition and behavior. Non-competitiveinhibition of the bacterial homologue LeuT by tricyclic antidepressants resulted...
aminocoumarins (including novobiocin and Coumermycin A1), which work by competitiveinhibition of energy transduction of DNA gyrase by binding to the ATPase active...
the antifolates that interfere with the use of folic acid; thus, competitiveinhibition can occur, and the presence of antimetabolites can have toxic effects...
prolyl hydroxylases and collagen prolyl-4-hydroxylases, through competitiveinhibition. 2-oxoglutarate-dependent dioxygenases require an iron cofactor...
enzymes can either be stimulated (enzyme induction) or inhibited (enzyme inhibition). If a drug is metabolized by a CYP450 enzyme and drug B blocks the activity...
agents, which prevent acetylcholine receptor activation through competitiveinhibition. Depolarizing muscle relaxants Succinylcholine (also known as suxamethonium...
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