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Diguanylate cyclase information


diguanylate cyclase
Crystal structure of diguanylate cyclase PleD in complex with c-di-GMP from Caulobacter crescentus; rendering based on PDB: 2WB4
Identifiers
EC no.2.7.7.65
CAS no.146316-82-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, diguanylate cyclase, also known as diguanylate kinase (EC 2.7.7.65), is an enzyme that catalyzes the chemical reaction:

2 Guanosine triphosphate ↔ 2 diphosphate + cyclic di-3',5'-guanylate

The substrates of diguanylate cyclases (DGCs) are two molecules of guanosine triphosphate (GTP) and the products are two molecules of diphosphate and one molecule of cyclic di-3’,5’-guanylate (cyclic di-GMP).

Degradation of cyclic di-GMP to guanosine monophosphate (GMP) is catalyzed by a phosphodiesterase (PDE).

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Diguanylate cyclase

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In enzymology, diguanylate cyclase, also known as diguanylate kinase (EC 2.7.7.65), is an enzyme that catalyzes the chemical reaction: 2 Guanosine triphosphate...

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GGDEF domain

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phosphorylation receiver or oxygen sensing domain. Its function is to act as a diguanylate cyclase and synthesize cyclic di-GMP, which is used as an intracellular signalling...

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RpoS

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expression of the curli structural and export proteins, and the diguanylate cyclase, adrA, which indirectly activates cellulose production. The rpoS...

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Vibrio parahaemolyticus

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correlates with tdh-/trh+ strains. GefA, a GGEEF domain containing diguanylate cyclase, has recently been characterized from the V. parahaemolyticus genome...

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Alteromonas macleodii

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copper concentrations. These strains possess an alteration in the diguanylate cyclase (DGC) genes, which control the expression of biofilms in A. macleodii...

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Shewanella woodyi

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Pak T; Boon EM (2010). "Characterization of a diguanylate cyclase from Shewanella woodyi with cyclase and phosphodiesterase activities". Mol Biosyst...

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RprA RNA

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stationary phase-induced biofilm regulator and ydaM, which encodes a diguanylate cyclase involved in activating csgD transcription. These two target genes...

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