Platelet glycoprotein VI (GPVI) is a glycoprotein receptor for collagen which is expressed in platelets. In humans, glycoprotein VI is encoded by the GP6 gene.[5]
It was first cloned in 2000 by several groups including that of Martine Jandrot-Perrus from INSERM.
^ abcGRCm38: Ensembl release 89: ENSMUSG00000078810 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ezumi Y, Uchiyama T, Takayama H (Oct 2000). "Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI". Biochemical and Biophysical Research Communications. 277 (1): 27–36. doi:10.1006/bbrc.2000.3624. PMID 11027634.
and 28 Related for: Platelet glycoprotein VI information
Platelet membrane glycoproteins are surface glycoproteins found on platelets (thrombocytes) which play a key role in hemostasis. When the blood vessel...
interaction with plateletglycoproteinVI. Binding of collagen to glycoproteinVI triggers a signaling cascade that results in activation of platelet integrins...
platelet can be divided into four zones, from peripheral to innermost:[citation needed] Peripheral zone – rich in glycoproteins required for platelet...
collagen receptors. Platelet membrane glycoproteins, mainly GPIa/IIa, GPVI and probably GPIV as well, function as receptors engaged in platelet adhesion to collagen...
certain integrins. Basigin also serves as a receptor for S100A9 and plateletglycoproteinVI, and basigin-1 acts as a receptor for the rod-derived cone viability...
from its ability to bind with high affinity to the platelet receptor for collagen, glycoprotein (GP) VI. It is, therefore, an important task to determine...
S2CID 34399027. Du X (May 2007). "Signaling and regulation of the plateletglycoprotein Ib-IX-V complex". Current Opinion in Hematology. 14 (3): 262–69...
association of Fc receptor gamma-chain with glycoproteinVI and their co-expression as a collagen receptor in human platelets". The Journal of Biological Chemistry...
García, Ángel (2023). "Role of SHP2 (PTPN11) in glycoproteinVI-dependent thrombus formation: Improved platelet responsiveness by the allosteric drug SHP099...
This gene encodes a type-I, integral membrane, heavily O-glycosylated glycoprotein with diverse distribution in human tissues. The physiological function...
integrin and causes inhibition of the platelet aggregation pathways that collagen is responsible for. The glycoproteinVI (GPVI) collagen receptor however...
chromosome 2. The zymogenic form of protein C is a vitamin K-dependent glycoprotein that circulates in blood plasma. Its structure is that of a two-chain...
extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to...
number of platelets in the blood, which can result in bruises and bleeding. Extremely low platelet counts may be temporarily boosted through platelet transfusions...
receptor gamma-chain after stimulation of the collagen receptor glycoproteinVI in human platelets". Eur. J. Biochem. 263 (3): 612–23. doi:10.1046/j.1432-1327...
macrophages and monocytes. After infection, a secreted glycoprotein, small soluble glycoprotein (sGP or GP) is synthesised. EBOV replication overwhelms...
platelets are activated by locally exposed collagen (glycoprotein (GP) VI receptor), locally generated thrombin (PAR1 and PAR4 receptors), platelet-derived...
receptor gamma-chain after stimulation of the collagen receptor glycoproteinVI in human platelets". European Journal of Biochemistry. 263 (3): 612–623. doi:10...
JM (Apr 2002). "Protein kinase B is regulated in platelets by the collagen receptor glycoproteinVI". J. Biol. Chem. 277 (15): 12874–8. doi:10.1074/jbc...
L-selectin and PSGL-1 or endoglycan, FimH and mannose, myosin and actin, plateletglycoprotein Ib and von Willebrand factor, and integrin alpha 5 beta 1 and fibronectin...
CXorf66 has been portrayed to have notable presence in the plasma and platelet. Based upon PaxDb data, CXorf66 has been found ranking in the top 5% for...
receptor gamma-chain after stimulation of the collagen receptor glycoproteinVI in human platelets". European Journal of Biochemistry. 263 (3): 612–623. doi:10...
force generation. In platelets, conditional knockout of talin-1 results in the inability to activate integrins in response to platelet agonists, resulting...
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