endoplasmic reticulum to Golgi vesicle-mediated transport
COPII vesicle coating
response to vitamin K
post-translational protein modification
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2153
14067
Ensembl
ENSG00000198734
ENSMUSG00000026579
UniProt
P12259
O88783
RefSeq (mRNA)
NM_000130
NM_007976
RefSeq (protein)
NP_000121
NP_032002
Location (UCSC)
Chr 1: 169.51 – 169.59 Mb
Chr 1: 163.98 – 164.05 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Coagulation factor V (Factor V), also less commonly known as proaccelerin or labile factor, is a protein involved in coagulation, encoded, in humans, by F5 gene.[5] In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor.[5] Factor V deficiency leads to predisposition for hemorrhage, while some mutations (most notably factor V Leiden) predispose for thrombosis.
^ abcGRCh38: Ensembl release 89: ENSG00000198734 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026579 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"F5 gene: MedlinePlus Genetics". medlineplus.gov. Retrieved 9 May 2024.
Coagulation factorV (FactorV), also less commonly known as proaccelerin or labile factor, is a protein involved in coagulation, encoded, in humans, by...
FactorV Leiden (rs6025 or F5 p.R506Q) is a variant (mutated form) of human factorV (one of several substances that helps blood clot), which causes an...
This process is optimized when factor Xa is complexed with activated co-factorV in the prothrombinase complex. Factor Xa is inactivated by protein Z-dependent...
Coagulation factor VIII (Factor VIII, FVIII, also known as anti-hemophilic factor (AHF)) is an essential blood clotting protein. In humans, it is encoded...
rates. Genetic factors include non-O blood type, deficiencies of antithrombin, protein C, and protein S and the mutations of factorV Leiden and prothrombin...
levels of a substance called von Willebrand factor, and parahaemophilia, which occurs due to low levels of factorV. Haemophilia A, B, and C prevent the intrinsic...
was identified in 1965, while the most common abnormalities (including factorV Leiden) were described in the 1990s. The most common conditions associated...
John Factor (October 8, 1892 – January 22, 1984), born Iakov Faktorowicz and widely known as Jake "The Barber" Factor, was a Prohibition-era gangster and...
Tissue factor, also called platelet tissue factor or Coagulation factor III, is a protein present in subendothelial tissue and leukocytes which plays a...
on prothrombin by activated Factor X (Xa). The activity of factor Xa is greatly enhanced by binding to activated FactorV (Va), termed the prothrombinase...
The utilization factor or use factor is the ratio of the time that a piece of equipment is in use to the total time that it could be in use. It is often...
thrombosis); Common causes include: cancer (leukaemia), factorV mutation (Leiden) – prevents FactorV inactivation leading to increased coagulability. Disseminated...
The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly...
The velocity factor (VF), also called wave propagation speed or velocity of propagation (VoP or v P {\displaystyle v_{\mathrm {P} }} ), of a transmission...
notably H. influenzae, need growth factors such as nicotinamide adenine dinucleotide (factorV or NAD) and hemin (factor X), which are inside red blood cells;...
menopausal hormone therapy and hormonal contraceptives) Genetic thrombophilia (factorV Leiden, prothrombin mutation G20210A, protein C deficiency, protein S deficiency...
following coagulation factors: I (fibrinogen), II (prothrombin), V (proaccelerin), VIII (anti-hemophilic factor), X (Stuart–Prower factor), XI (plasma thromboplastin...
Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV,: 6822 is a zymogen, that is, an inactive enzyme. The activated form plays...
Factor analysis is a statistical method used to describe variability among observed, correlated variables in terms of a potentially lower number of unobserved...
In electrical engineering, the power factor of an AC power system is defined as the ratio of the real power absorbed by the load to the apparent power...
constant volume (CV). It is sometimes also known as the isentropic expansion factor and is denoted by γ (gamma) for an ideal gas or κ (kappa), the isentropic...
Willebrand factor type D domain (vWD) is an evolutionarily-conserved protein domain found in, among others, the von Willebrand factor (vWF). vWF is a large...
lead to pulmonary embolism Ischemic stroke Hypercoagulable states (e.g., FactorV Leiden) — can lead to deep vein thrombosis Mechanical heart valves Myocardial...
as von Willebrand factor-cleaving protease (VWFCP)—is a zinc-containing metalloprotease enzyme that cleaves von Willebrand factor (vWf), a large protein...
Global Information
