Collagen receptors are membrane proteins that bind the extracellular matrix protein collagen, the most abundant protein in mammals.[1] They control mainly cell proliferation, migration and adhesion, coagulation cascade activation and they affect ECM structure by regulation of MMP (matrix metalloproteinases).
There are at least eight human collagen receptors.[2]
^Collagen+Receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Collagenreceptors are membrane proteins that bind the extracellular matrix protein collagen, the most abundant protein in mammals. They control mainly...
Platelet glycoprotein VI (GPVI) is a glycoprotein receptor for collagen which is expressed in platelets. In humans, glycoprotein VI is encoded by the...
Collagen (/ˈkɒlədʒən/) is the main structural protein in the extracellular matrix found in the body's various connective tissues. As the main component...
layer is disrupted, collagen and VWF anchor platelets to the subendothelium. Platelet GP1b-IX-V receptor binds with VWF; and GPVI receptor and integrin α2β1...
GPVI and probably GPIV as well, function as collagenreceptors, engaged in platelet adhesion to collagen. The leading role in the elimination of high-stress...
Collagen loss is the gradual decrease of levels of collagen in the body. Collagen is the main structural protein found in the body's various connective...
Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C-terminus is not removed in post-translational...
Agarwal G, Fridman R (March 2013). "Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling". The Journal of Biological...
and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium...
platelet function assay may give an abnormal collagen/epinephrine closure time, and in most cases, a normal collagen/ADP time. Type 2N may be considered if...
pressure. Convulxin acts as an agonist to the GPVI receptor, the major signalling receptor for collagen. This can cause the blood stream to burst, or the...
receptor gamma-chain with glycoprotein VI and their co-expression as a collagenreceptor in human platelets". The Journal of Biological Chemistry. 272 (38):...
prolonged bleeding time due to impaired aggregation response to fibrillar collagen.[citation needed] The presentation (signs/symptoms) of an individual with...
PDB for Human Integrin alpha 2 Moroi M, Jung SM (1997). "Platelet receptors for collagen". Thromb. Haemost. 78 (1): 439–44. doi:10.1055/s-0038-1657566. PMID 9198193...
mannose receptor family. Collagens I-IV bind this region with high affinity, while collagen V binds only weakly. Through this domain, the mannose receptor internalises...
integrin complexes which function as collagenreceptors. It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. These...
multimers to bind more tightly to their receptors on platelets (the alpha chains of glycoprotein Ib (GPIb) receptors). In the case of type 2B vWD, the gain-of-function...
JM (Apr 2002). "Protein kinase B is regulated in platelets by the collagenreceptor glycoprotein VI". J. Biol. Chem. 277 (15): 12874–8. doi:10.1074/jbc...
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