A schematic showing peripheral blood with plasma cell leukemia. Many plasma cells are seen mixed with red cells.
Specialty
Hematology and oncology
Plasma cell leukemia (PCL) is a plasma cell dyscrasia, i.e. a disease involving the malignant degeneration of a subtype of white blood cells called plasma cells. It is the terminal stage and most aggressive form of these dyscrasias, constituting 2% to 4% of all cases of plasma cell malignancies. PCL may present as primary plasma cell leukemia, i.e. in patients without prior history of a plasma cell dyscrasia or as secondary plasma cell dyscrasia, i.e. in patients previously diagnosed with a history of its predecessor dyscrasia, multiple myeloma. The two forms of PCL appear to be at least partially distinct from each other. In all cases, however, PCL is an extremely serious, life-threatening, and therapeutically challenging disease.[1][2]
^Fernández de Larrea C, Kyle RA, Durie BG, Ludwig H, Usmani S, Vesole DH, Hajek R, San Miguel JF, Sezer O, Sonneveld P, Kumar SK, Mahindra A, Comenzo R, Palumbo A, Mazumber A, Anderson KC, Richardson PG, Badros AZ, Caers J, Cavo M, LeLeu X, Dimopoulos MA, Chim CS, Schots R, Noeul A, Fantl D, Mellqvist UH, Landgren O, Chanan-Khan A, Moreau P, Fonseca R, Merlini G, Lahuerta JJ, Bladé J, Orlowski RZ, Shah JJ (2013). "Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group". Leukemia. 27 (4): 780–91. doi:10.1038/leu.2012.336. PMC 4112539. PMID 23288300.
^Granell M, Calvo X, Garcia-Guiñón A, Escoda L, Abella E, Martínez CM, Teixidó M, Gimenez MT, Senín A, Sanz P, Campoy D, Vicent A, Arenillas L, Rosiñol L, Sierra J, Bladé J, de Larrea CF (2017). "Prognostic impact of circulating plasma cells in patients with multiple myeloma: implications for plasma cell leukemia definition". Haematologica. 102 (6): 1099–1104. doi:10.3324/haematol.2016.158303. PMC 5451342. PMID 28255016.
and 27 Related for: Plasma cell leukemia information
Plasmacellleukemia (PCL) is a plasmacell dyscrasia, i.e. a disease involving the malignant degeneration of a subtype of white blood cells called plasma...
Plasmacells, also called plasma B cells or effector B cells, are white blood cells that originate in the lymphoid organs as B cells and secrete large...
myeloma (MM), also known as plasmacell myeloma and simply myeloma, is a cancer of plasmacells, a type of white blood cell that normally produces antibodies...
classified as a subtype of chronic lymphocytic leukemia (CLL). Hairy cellleukemia makes up about 2% of all leukemias, with fewer than 2,000 new cases diagnosed...
stage of secondary plasmacellleukemia. Thus, some patients with smouldering myeloma progress to multiple myeloma and plasmacellleukemia. Smouldering myeloma...
system. B cells produce antibody molecules which may be either secreted or inserted into the plasma membrane where they serve as a part of B-cell receptors...
minority of cases of multiple myeloma, chronic lymphocytic leukemia and plasmacellleukemia may also present with the t(11;14)(q13;q32) translocation...
Mast cellleukemia is an extremely aggressive subtype of acute myeloid leukemia that usually occurs de novo but can, rarely, evolve from transformation...
and overgrown by other cells. Estimates based on screening of leukemia-lymphoma cell lines suggest that about 15% of these cell lines are not representative...
thrombocytes, macrophages and mast cells; the lymphoid cell line produces B, T, NK and plasmacells. Lymphomas, lymphocytic leukemias, and myeloma are from the...
multiplying the red cell count by the mean cell volume. The hematocrit is slightly more accurate, as the PCV includes small amounts of blood plasma trapped between...
of the white blood cell differential can help to diagnose viral, bacterial and parasitic infections and blood disorders like leukemia. Not all results falling...
monoclonal gammopathy of undetermined significance (MGUS), amyloidosis, plasmacellleukemia and solitary plasmacytomas also produce an M-spike. Oligoclonal gammopathy...
irreversible. As a result, mast cells are coated with IgE, which is produced by plasmacells (the antibody-producing cells of the immune system). IgE antibodies...
need for many transfusions. Blood plasma compatibility is the inverse of red blood cell compatibility. Type AB plasma carries neither anti-A nor anti-B...
Finally the dividing cells differentiate into effector cells, known as plasmacells (for B cells), cytotoxic T cells, and helper T cells. Lymphoblasts can...
certain forms of cancer such as leukemia. Several types of stem cells are related to bone marrow. Hematopoietic stem cells in the bone marrow can give rise...
T cell and natural killer (NK) cell neoplasms T-cell prolymphocytic leukemia T-cell large granular lymphocyte leukemia Aggressive NK cellleukemia Adult...
into helper T cells, memory T cells, cytotoxic T cells), B cells (subdivided into plasmacells and memory B cells), and natural killer cells. Historically...
The murine leukemia viruses (MLVs or MuLVs) are retroviruses named for their ability to cause cancer in murine (mouse) hosts. Some MLVs may infect other...
the cells, and transports metabolic waste products away from those same cells. Blood is composed of blood cells suspended in blood plasma. Plasma, which...
Global Information