Hematopoietic stem cell transplantation information
Medical procedure to replace blood or immune stem cells
"Bone marrow transplant" redirects here. For the journal abbreviated Bone Marrow Transplant, see Bone Marrow Transplantation (journal).
Hematopoietic stem cell transplantation
Bone marrow transplant
ICD-9-CM
41.0
MeSH
D018380
MedlinePlus
003009
[edit on Wikidata]
Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce additional normal blood cells.[1][2][3][4][5][6] HSCT may be autologous (the patient's own stem cells are used), syngeneic (stem cells from an identical twin), or allogeneic (stem cells from a donor).[4][5]
It is most often performed for patients with certain cancers of the blood or bone marrow, such as multiple myeloma, leukemia, some types of lymphoma and immune deficiencies.[5] In these cases, the recipient's immune system is usually suppressed with radiation or chemotherapy before the transplantation. Infection and graft-versus-host disease are major complications of allogeneic HSCT.[5]
HSCT remains a dangerous procedure with many possible complications; it is reserved for patients with life-threatening diseases. As survival following the procedure has increased, its use has expanded beyond cancer to autoimmune diseases[7][8] and hereditary skeletal dysplasias, notably malignant infantile osteopetrosis[9][10] and mucopolysaccharidosis.[11]
^Monga I, Kaur K, Dhanda S (March 2022). "Revisiting hematopoiesis: applications of the bulk and single-cell transcriptomics dissecting transcriptional heterogeneity in hematopoietic stem cells". Briefings in Functional Genomics. 21 (3): 159–176. doi:10.1093/bfgp/elac002. PMID 35265979.
^Nabarrete, J. M.; Pereira, A. Z.; Garófolo, A.; Seber, A.; Venancio, A. M.; Grecco, C. E.; Bonfim, C. M.; Nakamura, C. H.; Fernandes, D.; Campos, D. J.; Oliveira, F. L.; Cousseiro, F. K.; Rossi, F. F.; Gurmini, J.; Viani, K. H.; Guterres, L. F.; Mantovani, L. F.; Darrigo Lg, Junior; Albuquerque, M. I.; Brumatti, M.; Neves, M. A.; Duran, N.; Villela, N. C.; Zecchin, V. G.; Fernandes, J. F. (2021). "Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Children and adolescents". Einstein. 19: eAE5254. doi:10.31744/einstein_journal/2021AE5254. PMC 8664291. PMID 34909973.
^ abFelfly H, Haddad GG (2014). "Hematopoietic stem cells: potential new applications for translational medicine". Journal of Stem Cells. 9 (3): 163–197. PMID 25157450.
^ abcdPark B, Yoo KH, Kim C (December 2015). "Hematopoietic stem cell expansion and generation: the ways to make a breakthrough". Blood Research. 50 (4): 194–203. doi:10.5045/br.2015.50.4.194. PMC 4705045. PMID 26770947.
^Mahla RS (2016). "Stem Cells Applications in Regenerative Medicine and Disease Therapeutics". International Journal of Cell Biology. 2016 (7): 6940283. doi:10.1155/2016/6940283. PMC 4969512. PMID 27516776.
^Tyndall A, Fassas A, Passweg J, Ruiz de Elvira C, Attal M, Brooks P, et al. (October 1999). "Autologous haematopoietic stem cell transplants for autoimmune disease – feasibility and transplant-related mortality. Autoimmune Disease and Lymphoma Working Parties of the European Group for Blood and Marrow Transplantation, the European League Against Rheumatism and the International Stem Cell Project for Autoimmune Disease". Bone Marrow Transplantation. 24 (7): 729–734. doi:10.1038/sj.bmt.1701987. PMID 10516675.
^Burt RK, Loh Y, Pearce W, Beohar N, Barr WG, Craig R, et al. (February 2008). "Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases". JAMA. 299 (8): 925–936. doi:10.1001/jama.299.8.925. PMID 18314435.
^EL-Sobky TA, El-Haddad A, Elsobky E, Elsayed SM, Sakr HM (March 2017). "Reversal of skeletal radiographic pathology in a case of malignant infantile osteopetrosis following hematopoietic stem cell transplantation". The Egyptian Journal of Radiology and Nuclear Medicine. 48 (1): 237–243. doi:10.1016/j.ejrnm.2016.12.013.
^Hashemi Taheri AP, Radmard AR, Kooraki S, Behfar M, Pak N, Hamidieh AA, Ghavamzadeh A (September 2015). "Radiologic resolution of malignant infantile osteopetrosis skeletal changes following hematopoietic stem cell transplantation". Pediatric Blood & Cancer. 62 (9): 1645–1649. doi:10.1002/pbc.25524. PMID 25820806. S2CID 11287381.
^Langereis EJ, den Os MM, Breen C, Jones SA, Knaven OC, Mercer J, et al. (March 2016). "Progression of Hip Dysplasia in Mucopolysaccharidosis Type I Hurler After Successful Hematopoietic Stem Cell Transplantation". The Journal of Bone and Joint Surgery. American Volume. 98 (5): 386–395. doi:10.2106/JBJS.O.00601. PMID 26935461. S2CID 207284951.
and 23 Related for: Hematopoietic stem cell transplantation information
Hematopoieticstem-celltransplantation (HSCT) is the transplantation of multipotent hematopoieticstemcells, usually derived from bone marrow, peripheral...
Hematopoieticstemcells (HSCs) are the stemcells that give rise to other blood cells. This process is called haematopoiesis. In vertebrates, the first...
2016[update], the only established medical therapy using stemcells is hematopoieticstemcelltransplantation, first performed in 1958 by French oncologist Georges...
stemcelltransplant to a sibling that is affected with a fatal disease, such as cancer or Fanconi anemia, that can best be treated by hematopoietic stem...
globulin—combined with corticosteroids, chemotherapy, and ciclosporin. Hematopoieticstemcelltransplantation is also used, especially for patients under 30 years of...
changes in the blood cells and bone marrow. Treatments may include supportive care, drug therapy, and hematopoieticstemcelltransplantation. Supportive care...
patients after hematopoieticstem-celltransplantation: long-term follow-up suggests an increased risk for recurrence". Transplantation. 90 (11): 1243–1244...
the blood cell count gets too low; this is called autologous hematopoieticstemcelltransplantation, or high dose therapy with stemcell rescue. Research...
the transplantation. Infection and graft-versus-host disease are major complications of allogeneic HSCT. Haematopoietic stemcelltransplantation remains...
infection, radiation or chemotherapy. In recent decades, however, stemcell and celltransplantation has gained significant interest by researchers as a potential...
These bone marrow stemcells do not contribute to the formation of blood cells, and so do not express the hematopoieticstemcell marker CD34. They are...
blood stemcelltransplantation (PBSCT), also called "Peripheral stemcell support", is a method of replacing blood-forming stemcells. Stemcells can be...
been the standard treatment for CGD for several years. Hematopoieticstemcelltransplantation from a matched donor is curative although not without significant...
no known cure for Krabbe disease, bone marrow transplantation or hematopoieticstemcelltransplantation (HSCT) has been shown to benefit cases early in...
KSL cells in cell biology are an early form of mouse/murine hematopoieticstemcells. Characteristics are Kit (+), Sca-1 (+) and Lin (-). HSCs [Hematopoietic...
setting of post lung transplantation and hematopoieticstemcelltransplant (HSCT). Patients who develop BOS post lung transplant vary in disease latency...
marrow transplantation and hematopoieticstemcelltransplantation (HSCT) have been used as treatments in some studies. While transplantation has provided...
Global Information