Micrograph showing mantle cell lymphoma (bottom of image) in a biopsy of the terminal ileum. H&E stain.
Specialty
Hematology and oncology
Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma, comprising about 6% of cases.[1][2] It is named for the mantle zone of the lymph nodes where it develops.[3][4] The term 'mantle cell lymphoma' was first adopted by Raffeld and Jaffe in 1991.[5]
MCL is a subtype of B-cell lymphoma, due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles. MCL cells generally over-express cyclin D1 due to the t(11:14) translocation,[6] a chromosomal translocation in the DNA.
Lymph nodes of the head and neck, from Gray's Anatomy (click image to enlarge)
^"Mantle Cell Lymphoma Facts" (PDF). lls.org. Archived from the original (PDF) on 9 February 2015. Retrieved 10 April 2018.
^Skarbnik AP, Goy AH (January 2015). "Mantle cell lymphoma: state of the art". Clin Adv Hematol Oncol. 13 (1): 44–55. PMID 25679973.
^"Mantle cell lymphoma". www.cancerresearchuk.org. Retrieved 8 October 2023.
^"Lymphoma Action | Mantle cell lymphoma". Lymphoma Action. 26 February 2021. Retrieved 8 October 2023.
^Huang, Zoufang; Chavda, Vivek P.; Bezbaruah, Rajashri; Dhamne, Hemant; Yang, Dong-Hua; Zhao, Hong-Bing (31 March 2023). "CAR T-Cell therapy for the management of mantle cell lymphoma". Molecular Cancer. 22 (1): 67. doi:10.1186/s12943-023-01755-5. ISSN 1476-4598. PMC 10064560. PMID 37004047.
^"t(11;14)(q13;q32) IGH/CCND1". atlasgeneticsoncology.org. Retrieved 10 April 2018.
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