Figure 1: Role of PDE3 in cAMP- and cGMP-mediated signal transduction. PK-A: Protein kinase A (cAMP dependent). PK-G: Protein kinase G (cGMP-dependent).
PDE3 is a phosphodiesterase. The PDEs belong to at least eleven related gene families, which are different in their primary structure, substrate affinity, responses to effectors, and regulation mechanism.
Most of the PDE families are composed of more than one gene. PDE3 is clinically significant because of its role in regulating heart muscle, vascular smooth muscle and platelet aggregation. PDE3 inhibitors have been developed as pharmaceuticals, but their use is limited by arrhythmic effects and they can increase mortality in some applications.
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PDE3 is a phosphodiesterase. The PDEs belong to at least eleven related gene families, which are different in their primary structure, substrate affinity...
A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which...
A PDE3 inhibitor is a drug which inhibits the action of the phosphodiesterase enzyme PDE3. They are used for the therapy of acute heart failure and cardiogenic...
3′,5′-cyclic-nucleotide phosphodiesterases (EC 3.1.4.17) are a family of phosphodiesterases. Generally, these enzymes hydrolyze a nucleoside 3′,5′-cyclic...
failure, low platelets, and low white blood cells. Cilostazol is a phosphodiesterase3 inhibitor which works by inhibiting platelet aggregation and dilating...
medication. It is a calcium sensitizer and a selective inhibitor of phosphodiesterase3 (PDE3) with positive inotropic and vasodilator effects. Pimobendan...
an imidazole phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure and is selective for phosphodiesterase3. Boldt J, Suttner...
A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation...
pulmonary vasodilator used in patients who have heart failure. It is a phosphodiesterase3 inhibitor that works to increase the heart's contractility and decrease...
Sphingomyelin phosphodiesterase D (EC 3.1.4.41, sphingomyelinase D) is an enzyme of the sphingomyelin phosphodiesterase family with systematic name sphingomyelin...
Amrinone, also known as inamrinone, and sold as Inocor, is a pyridine phosphodiesterase3 inhibitor. It is a drug that may improve the prognosis in patients...
A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase...
microtubule dynamics of the testes. Female mammals – orally administered phosphodiesterase3 inhibitor ORG 9935 daily before and during ovulation, which blocks...
euthanasia product containing phenytoin and pentobarbital pimobendan – phosphodiesterase3 inhibitor used to manage heart failure in dogs pirlimycin – antimicrobial...
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 is an enzyme that in humans is encoded by the ENPP3 gene. The protein encoded by this...
Phosphodiesterase 1, PDE1, EC 3.1.4.1, systematic name oligonucleotide 5′-nucleotidohydrolase) is a phosphodiesterase enzyme also known as calcium- and...
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A is an enzyme that in humans is encoded by the PDE10A gene. Various cellular responses are...
Sphingomyelin phosphodiesterase3 is an enzyme that in humans is encoded by the SMPD3 gene. GRCh38: Ensembl release 89: ENSG00000103056 – Ensembl, May...
Vesnarinone (INN) is a cardiotonic agent. A mixed phosphodiesterase3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic...
in a serious drop in blood pressure. Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates...
Adibendan is an inhibitor of phosphodiesterase3. It has been tested in dogs for its effects on heart output and dilation of blood vessels. Dorszewski...
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