3′,5′-cyclic-nucleotide phosphodiesterases (EC 3.1.4.17) are a family of phosphodiesterases. Generally, these enzymes hydrolyze a nucleoside 3′,5′-cyclic phosphate to a nucleoside 5′-phosphate:
They thus control the cellular levels of the cyclic second messengers and the rates of their degradation.[1]
Some examples of nucleoside 3′,5′-cyclic phosphate include:
3′,5′-cyclic AMP
3′,5′-cyclic dAMP
3′,5′-cyclic IMP
3′,5′-cyclic GMP
3′,5′-cyclic CMP
There are 11 distinct phosphodiesterase families (PDE1–PDE11) with a variety in isoforms and splicing having unique three-dimensional structure, kinetic properties, modes of regulation, intracellular localization, cellular expression, and inhibitor sensitivities.[1]
5′-cyclic-nucleotidephosphodiesterases (EC 3.1.4.17) are a family of phosphodiesterases. Generally, these enzymes hydrolyze a nucleoside 3′,5′-cyclic phosphate...
A cyclicnucleotide (cNMP) is a single-phosphate nucleotide with a cyclic bond arrangement between the sugar and phosphate groups. Like other nucleotides...
A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclicnucleotidephosphodiesterases, which...
works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels...
Cyclic guanosine monophosphate (cGMP) is a cyclicnucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic...
PMID 16968949. S2CID 7397281. Lugnier C (March 2006). "Cyclicnucleotidephosphodiesterase (PDE) superfamily: a new target for the development of specific...
the type IV, cyclic AMP (cAMP)-specific, cyclicnucleotidephosphodiesterase (PDE) family. Cyclicnucleotides are important second messengers that regulate...
function of ion channels such as the HCN channels and a few other cyclicnucleotide-binding proteins such as Epac1 and RAPGEF2. cAMP is associated with...
and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclicnucleotide to the corresponding...
atherosclerotic lesions or during restenosis. Lugnier C (March 2006). "Cyclicnucleotidephosphodiesterase (PDE) superfamily: a new target for the development of specific...
3',5'-cyclicphosphodiesterase 4A is an enzyme that in humans is encoded by the PDE4A gene. The protein encoded by this gene belongs to the cyclic nucleotide...
cAMP-specific 3',5'-cyclicphosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene. The PDE4D gene is complex and has at least 9...
"Positive inotropic effect of the inhibition of cyclic GMP-stimulated 3',5'-cyclicnucleotidephosphodiesterase (PDE2) on guinea pig left atria in eu- and...
Calcium/calmodulin-dependent 3',5'-cyclicnucleotidephosphodiesterase 1C is an enzyme that in humans is encoded by the PDE1C gene. GRCh38: Ensembl release...
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene. The 3',5'-cyclicnucleotides cAMP and cGMP...
a 3'5'-cyclicnucleotidephosphodiesterase (PDE) that converts 3'5'-cyclic adenosine monophosphate (cAMP) to 5'AMP as part of cyclicnucleotide signaling...
Calcium/calmodulin-dependent 3',5'-cyclicnucleotidephosphodiesterase 1B is an enzyme that in humans is encoded by the PDE1B gene. GRCh38: Ensembl release...
of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclicnucleotidephosphodiesterase". Biochem Biophys Res Commun. 250 (3): 751–6. doi:10.1006/bbrc...
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