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Cilostazol information


Cilostazol
Clinical data
Pronunciation/sɪˈlɒstəzɒl/
sil-OS-tə-zol
Trade namesPletal
AHFS/Drugs.comMonograph
MedlinePlusa601038
License data
  • US DailyMed: Cilostazol
Routes of
administration
By mouth (tablets)
ATC code
  • B01AC23 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: WARNING[1]Rx-only
Pharmacokinetic data
Protein binding95–98%
MetabolismLiver (CYP3A4- and CYP2C19-mediated)
Elimination half-life11–13 hours
ExcretionKidney
Identifiers
IUPAC name
  • 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-
    3,4-dihydro-2(1H)-quinolinone
CAS Number
  • 73963-72-1 checkY
PubChem CID
  • 2754
IUPHAR/BPS
  • 7148
DrugBank
  • DB01166 checkY
ChemSpider
  • 2652 checkY
UNII
  • N7Z035406B
KEGG
  • D01896 checkY
ChEBI
  • CHEBI:31401 checkY
ChEMBL
  • ChEMBL799 checkY
CompTox Dashboard (EPA)
  • DTXSID9045132 Edit this at Wikidata
ECHA InfoCard100.215.897 Edit this at Wikidata
Chemical and physical data
FormulaC20H27N5O2
Molar mass369.469 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • O=C4Nc3c(cc(OCCCCc1nnnn1C2CCCCC2)cc3)CC4
InChI
  • InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26) checkY
  • Key:RRGUKTPIGVIEKM-UHFFFAOYSA-N checkY
  (verify)

Cilostazol, sold under the brand name Pletal among others, is a medication used to help the symptoms of intermittent claudication in peripheral vascular disease.[2] If no improvement is seen after 3 months, stopping the medication is reasonable.[3] It may also be used to prevent stroke.[2] It is taken by mouth.[2]

Common side effects include headache, diarrhea, dizziness, and cough.[2] Serious side effects may include decreased survival in those with heart failure, low platelets, and low white blood cells.[2] Cilostazol is a phosphodiesterase 3 inhibitor which works by inhibiting platelet aggregation and dilating arteries.[2]

Cilostazol was approved for medical use in the United States in 1999.[2] It is available as a generic medication.[3] In 2019, it was the 347th most commonly prescribed medication in the United States, with more than 800 thousand prescriptions.[4]

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
  2. ^ a b c d e f g "Cilostazol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 23 March 2019.
  3. ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 231–232. ISBN 9780857113382.
  4. ^ "Cilostazol - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.

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compensatory pause.[citation needed] Third degree AV block can be treated with Cilostazol which acts to increase Ventricular escape rate Ouabain infusion decreases...

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acute heart failure, so they have to be applied under close observation. Cilostazol is used for the treatment of intermittent claudication. This drug has...

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Peripheral artery disease

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improve outcomes. Medications, including statins, ACE inhibitors, and cilostazol, may also help. Aspirin, which helps with thinning the blood and thus...

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Intermittent claudication

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agents (aspirin and clopidogrel), naftidrofuryl, pentoxifylline, and cilostazol (selective PDE3 inhibitor) are used for the treatment of intermittent...

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Claudication

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effects of the vasoconstriction associated with vascular claudication. Cilostazol (trade name: Pletal) is FDA approved for intermittent claudication. It...

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latency to seizure incidence and decreasing the seizure duration in vivo. Cilostazol (Pletal) inhibits PDE3. This inhibition allows red blood cells to be more...

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Antiplatelet drug

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Nucleotide

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List of phosphodiesterase inhibitors

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CYP3A4

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