Enoximone information

Enoximone
Clinical data
Trade names	Perfan
AHFS/Drugs.com	International Drug Names
Routes of; administration	Intravenous
ATC code	C01CE03 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only);
Pharmacokinetic data
Bioavailability	50% (oral)
Protein binding	85%
Metabolism	Liver (oxidation)
Elimination half-life	4 to 10 hours
Excretion	Renal (60 to 70%)
Identifiers
	IUPAC name 4-Methyl-5-{[4-(methylsulfanyl)phenyl]carbonyl}-2,3-dihydro-1H-imidazol-2-one;
CAS Number	77671-31-9 ;
PubChem CID	53708;
DrugBank	DB04880 ;
ChemSpider	48492 ;
UNII	C7Z4ITI7L7;
KEGG	D04004 ;
ChEMBL	ChEMBL249856 ;
CompTox Dashboard (EPA)	DTXSID8045147 ;
Chemical and physical data
Formula	C12H12N2O2S
Molar mass	248.30 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	255 to 258 °C (491 to 496 °F) (decomposes)
	SMILES O=C(/C1=C(/NC(=O)N1)C)c2ccc(SC)cc2;
	InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) ; Key:ZJKNESGOIKRXQY-UHFFFAOYSA-N ;
	(verify)

Enoximone (INN, trade name Perfan) is an imidazole phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure and is selective for phosphodiesterase 3.^[1]

^ Boldt J, Suttner S (September 2007). "Combined use of ultra-short acting beta-blocker esmolol and intravenous phosphodiesterase 3 inhibitor enoximone". Expert Opin Pharmacother. 8 (13): 2135–47. doi:10.1517/14656566.8.13.2135. PMID 17714066. S2CID 46021219.

[pmid17714066-1] Boldt J, Suttner S (September 2007). "Combined use of ultra-short acting beta-blocker esmolol and intravenous phosphodiesterase 3 inhibitor enoximone". Expert Opin Pharmacother. 8 (13): 2135–47. doi:10.1517/14656566.8.13.2135. PMID 17714066. S2CID 46021219.

Enoximone information

and 28 Related for: Enoximone information

Enoximone

Antihypotensive agent

Inotrope

Phosphodiesterase 3

PDE3 inhibitor

List of phosphodiesterase inhibitors

Phosphodiesterase inhibitor

Caffeine

Tadalafil

Theophylline

Papaverine

Pentoxifylline

Apremilast

Pimobendan

Milrinone

Icariin

Tofisopam

Sildenafil

PDE5 inhibitor

Theobromine

Vinpocetine

Avanafil

Crisaborole

Vardenafil

ATC code C01

C12H12N2O2S

Dipyridamole

Aminophylline