Amrinone, also known as inamrinone, and sold as Inocor, is a pyridine phosphodiesterase 3 inhibitor.[1] It is a drug that may improve the prognosis in patients with congestive heart failure.[2] Amrinone has been shown to increase the contractions initiated in the heart by high-gain calcium induced calcium release (CICR).[3] The positive inotropic effect of amrinone is mediated by the selective enhancement of high-gain CICR, which contributes to the contraction of myocytes by phosphorylation through cAMP dependent protein kinase A (PKA) and Ca2+ calmodulin kinase pathways.[3]
^Hamada Y, Kawachi K, Yamamoto T, Nakata T, Kashu Y, Sato M, Watanabe Y (August 1999). "Effects of single administration of a phosphodiesterase III inhibitor during cardiopulmonary bypass: comparison of milrinone and amrinone". Japanese Circulation Journal. 63 (8): 605–609. doi:10.1253/jcj.63.605. PMID 10478810.
^Cite error: The named reference AJC.1981.48 was invoked but never defined (see the help page).
^ abXiong W, Ferrier GR, Howlett SE (August 2004). "Diminished inotropic response to amrinone in ventricular myocytes from myopathic hamsters is linked to depression of high-gain Ca2+-induced Ca2+ release". The Journal of Pharmacology and Experimental Therapeutics. 310 (2): 761–773. doi:10.1124/jpet.103.064873. PMID 15064331. S2CID 6036283.
Amrinone, also known as inamrinone, and sold as Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may improve the prognosis in patients...
are used for the therapy of acute heart failure and cardiogenic shock. Amrinone, milrinone and enoximone are used clinically for short-term treatment of...
Oxindole PDP (9-(6-Phenyl-2-oxohex-3-yl)-2-(3,4-dimethoxybenzyl)-purin-6-one) Amrinone, milrinone and enoximone are used clinically for short-term treatment of...