A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which...
management of psoriatic arthritis is apremilast, a small molecule phosphodiesterase-4 inhibitor approved for use by the FDA in 2014. By inhibiting PDE4...
A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation...
structurally related to papaverine, and is a selective inhibitor of phosphodiesterase-4, and has no anticholinergic effects. It is available in Asia,[specify]...
arthritis. The drug acts as a selective inhibitor of the enzyme phosphodiesterase4 (PDE4) and inhibits spontaneous production of TNF-alpha from human...
also been shown to decrease neuronal cell death. Phosphodiesterase4 is a member of the phosphodiesterase family of proteins that cleave phosphodiester bonds...
application site (including burning or stinging). Crisaborole is a phosphodiesterase4 (PDE-4) inhibitor, although its specific mechanism of action in atopic...
(Otezla, Celgene) is an oral small-molecule inhibitor of the enzyme phosphodiesterase4, which plays an important role in chronic inflammation associated...
that acts as a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). It has anti-inflammatory effects and is used as an orally administered...
reuptake inhibitor (Ki = 1.4 nM), and has also been found to behave as a weak inhibitor of the enzyme phosphodiesterase4 (PDE4) (Ki = 7,800 nM). In an...
cAMP-specific 3',5'-cyclic phosphodiesterase 4A is an enzyme that in humans is encoded by the PDE4A gene. The protein encoded by this gene belongs to...
phenotype of COPD, the phosphodiesterase-4 inhibitor roflumilast may decrease significant exacerbations. Chronic bronchitis affects about 3.4% to 22% of the general...
mepyramine, burimamide and metiamide. Recent studies have found that phosphodiesterase4 (PDE4) inhibitors, such as Rolipram, cause emesis as one of their...
Phosphodiesterase 1, PDE1, EC 3.1.4.1, systematic name oligonucleotide 5′-nucleotidohydrolase) is a phosphodiesterase enzyme also known as calcium- and...
Sphingomyelin phosphodiesterase D (EC 3.1.4.41, sphingomyelinase D) is an enzyme of the sphingomyelin phosphodiesterase family with systematic name sphingomyelin...
A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase...
Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s. It...
asthmatic features or features suggesting steroid responsiveness. Phosphodiesterase-4 inhibitors (PDE4 inhibitors) are anti-inflammatories that improve...
is an anti-inflammatory drug used mainly in Japan, which acts as a phosphodiesterase inhibitor, inhibiting the PDE4 subtype to the greatest extent, but...
adrenaline. cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase. cAMP is a second messenger, used for intracellular signal transduction...
hydroxychloroquine can disturb the glucose homeostasis. Recently selective phosphodiesterase4 (PDE4) inhibitors like apremilast (a thalidomide derivative), roflumilast...
(COPD). It is orally active and acts as a selective phosphodiesterase-4 inhibitor. Phosphodiesterase (PDE) inhibitors, such as theophylline, have been used...
a selective serotonin reuptake inhibitor; Ki = 27 nM) and also a phosphodiesterase4 (PDE4) inhibitor (Ki = 470 nM). Mesembrine is another alkaloid constituent...
AMP phosphodiesterase inhibitors suppress interleukin-2 release from murine splenocytes by interacting with a 'low-affinity' phosphodiesterase4 conformer"...
Atizoram (CP-80633) is a phosphodiesterase4 inhibitor. Wright, K. F.; Turner, C. R.; Jayasinghe-Beck, R.; Cohen, V. L.; Cheng, J. B.; Watson, J. W. (August...
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