Milrinone, one of the first PDE3 inhibitors used clinically
A PDE3 inhibitor is a drug which inhibits the action of the phosphodiesterase enzyme PDE3. They are used for the therapy of acute heart failure and cardiogenic shock.
A PDE3inhibitor is a drug which inhibits the action of the phosphodiesterase enzyme PDE3. They are used for the therapy of acute heart failure and cardiogenic...
they are not studied for that indication any longer. Nonetheless, the PDE3inhibitor milrinone is approved for use in heart failure in intravenous form....
Persantine and others) is a nucleoside transport inhibitor and a PDE3inhibitor medication that inhibits blood clot formation[dead link] when given chronically...
and PDE-7 may become enhanced. For example, Milrinone (a selective PDE3inhibitor) improved oxygenation and survival of neonates with MAS. Arachidonic...
medication. It is a calcium sensitizer and a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilator effects. Pimobendan...
inhibitor or a non-selective phosphodiesterase inhibitor, depending on the dose. Piclamilast, a more potent inhibitor than rolipram. Luteolin, supplement extracted...
incidence and decreasing the seizure duration in vivo. Cilostazol (Pletal) inhibitsPDE3. This inhibition allows red blood cells to be more able to bend. This...
A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase...
clopidogrel), naftidrofuryl, pentoxifylline, and cilostazol (selective PDE3inhibitor) are used for the treatment of intermittent claudication. However, medications...
CYP3A4 inhibitor) increases the drug's maximum concentration by around 50%. Cilostazol is a selective inhibitor of phosphodiesterase type 3 (PDE3) with...
which mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor. Bucladesine is a cell permeable cAMP analog. The compound is used in...
often in combination with other medications such as sildenafil. Targeting PDE3 with optimal doses and timing, milrinone prevents allergic inflammation in...
Enoximone (INN, trade name Perfan) is an imidazole phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure and is selective...
contractility, vasodilator. Acts by inhibiting the breakdown of both cAMP and cGMP by the phosphodiesterase (PDE3) enzyme. There is a long-standing controversy...
of heart disease. It acts as a selective PDE3inhibitor. It is no longer available. Phosphodiesterase inhibitor David J. Triggle (1996). Dictionary of Pharmacological...
Adibendan is an inhibitor of phosphodiesterase 3. It has been tested in dogs for its effects on heart output and dilation of blood vessels. Dorszewski...
hydrolyzes cyclic AMP to regulate human bronchial tone (along with PDE3). Yet as a PDE4 inhibitor, glaucine possesses very low potency. Glaucine has also recently...
Vesnarinone (INN) is a cardiotonic agent. A mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic...
Zardaverine is a dual-selective PDE3/4 phosphodiesterase inhibitor. Studies in vitro suggest that it may have useful anti-cancer properties. Kümmerle,...
this may result in a serious drop in blood pressure. Tadalafil is a PDE5 inhibitor which increases blood flow to the penis. It also dilates blood vessels...
Tofisopam as a PDE10A inhibitor. WIPO Patent WO/2007/082546 "Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers". FDA....
Avanafil is a PDE5 inhibitor approved for erectile dysfunction by the FDA on April 27, 2012 and by EMA on June 21, 2013. Avanafil is sold under the brand...
for inhibitor potency and differences between isotypes of PDE in the Q2 pocket can be exploited for selectivity between isotypes. Drugs that inhibit PDE5...
is a potent adenosine deaminase inhibitor, which also acts as a phosphodiesterase inhibitor that selectively inhibits phosphodiesterase type 2 (PDE2)...
It is a PDE5 inhibitor. It is taken by mouth. Vardenafil's indications and contraindications are the same as with other PDE5 inhibitors; it is closely...
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