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Phage coat Gp8
Single subunit of coat protein
Identifiers
Symbol
Phage_Coat_Gp8
Pfam
PF05371
Pfam clan
CL0371
InterPro
IPR008020
SCOP2
1fdm / SCOPe / SUPFAM
OPM superfamily
67
OPM protein
1ifk
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
In molecular biology, a phage major coat protein is an alpha-helical protein that forms a viral envelope of filamentous bacteriophages. These bacteriophages are flexible rods, about one to two micrometres long and six nm in diameter, with a helical shell of protein subunits surrounding a DNA core. The approximately 50-residue subunit of the major coat protein is largely alpha-helix, and the axis of the alpha-helix makes a small angle with the axis of the virion. The protein shell can be considered in three sections: the outer surface, occupied by the N-terminal region of the subunit and rich in acidic residues that give the virion a low isoelectric point; the interior of the shell (including a 19-residue stretch of apolar side-chains) where protein subunits interact, mainly with each other; and the inner surface (occupied by the C-terminal region of the subunit), rich in positively charged residues that interact with the DNA core.[1]
^Marvin DA, Hale RD, Nave C, Helmer-Citterich M (January 1994). "Molecular models and structural comparisons of native and mutant class I filamentous bacteriophages Ff (fd, f1, M13), If1 and IKe" (PDF). J. Mol. Biol. 235 (1): 260–86. doi:10.1016/S0022-2836(05)80032-4. hdl:2108/15515. PMID 8289247.
and 28 Related for: Phage major coat protein information
In molecular biology, a phagemajorcoatprotein is an alpha-helical protein that forms a viral envelope of filamentous bacteriophages. These bacteriophages...
connect proteins with the genetic information that encodes them. In this technique, a gene encoding a protein of interest is inserted into a phagecoat protein...
in the case of the m13 phage is 6407 nucleotides long and is encapsulated in approximately 2700 copies of the majorcoatprotein p8, and capped with about...
Glycophorin A dimer Inovirus (filamentous phage) majorcoatprotein Pilin Pulmonary surfactant-associated protein Monoamine oxidases A and B Fatty acid amide...
purposes the phages in the Ff group can be considered as interchangeable. Five gene products are part of the virion: the majorcoatprotein (p8) and the...
This is done as the phage genome supercoils and the secondary structure formed by such supercoiling attracts a primosome protein complex. This translocates...
pulling the phage toward the bacterium. Fusion of the viral envelope with the bacterial outer membrane is facilitated by the phageprotein, P6. The muralytic...
chromosome and enter the lytic cycle, where they undergo DNA copying, protein synthesis, phage assembly, and lysis. Since the bacteriophage's genetic information...
polypeptides with phagecoatprotein genes. Protein variants expressed on phage surfaces are selected by binding with immobilized targets in vitro. Phages with selected...
their positive effects in the environment, are used in phage display techniques for screening proteins DNA sequences. They are a powerful tool in molecular...
GroEL protein to assist in the correct folding and assembly of the majorphage head capsid protein of the phage, gp23. Chaperonin Heat shock protein GRCh38:...
information required to synthesize progeny phage particles. They used radioactivity to tag the bacteriophage's proteincoat with radioactive sulphur and DNA with...
of DNA or RNA that encode the structure of the proteins by which the virus acts; (ii) a proteincoat, the capsid, which surrounds and protects the genetic...
bacteriophage with coated antigen in microtiter plates. The washing step comes after the capturing step to wash away the unbound phages from solid surface...
information in the form of either DNA or RNA) surrounded by a capsid (a proteincoat protecting the genetic material). The shapes of these virus particles...
and of proteins within lipid bilayers. During assembly of the bacteriophage (phage) T4 virion, the morphogenetic proteins encoded by the phage genes interact...
DMC1 in eukaryotes, RadA in archaea, and UvsX in T4 phage. Related single stranded binding proteins that are important for homologous recombination, and...
ts TMV coatproteins as models for misfolded (toxic) proteins in the host plant cell and in transfected animal cells Synthesis of active phage Q beta...
polymerase catalyzes the phosphoryl transfer during DNA replication of the T7 phage. As shown in Figure 2, the 3’ hydroxyl group of a primer acts as a nucleophile...
first to determine the sequence of a gene: that of bacteriophage MS2 coatprotein. The subsequent development of chain-termination DNA sequencing in 1977...
implants. After implantation, the surface of these devices becomes coated with host proteins, which provide a rich surface for bacterial attachment and biofilm...
viral replication. Uncoating is defined by the removal of the virion's protein "coat" and the release of its genetic material. This step occurs in the same...
cellular machinery of mycobacteria to produce additional phages, such viruses can be used in phage therapy for eukaryotic hosts, as they would die alongside...
agents especially SDS separation of protein subunit (Weber and Osborn) 1970 – Lämmli separated 28 components of T4 phage using a stacking gel and SDS 1972...
W; King, J (1978). "Structure of phage P22 coatprotein aggregates formed in the absence of the scaffolding protein". Journal of Molecular Biology. 126...
hematopoietic genetics and cancer Bruce Alberts (born 1938), US biochemist, phage worker, studied DNA replication and cell division Lihadh Al-Gazali (born...
agricultural crops. Viroid RNA is not protected by a proteincoat, and it does not encode any proteins, only acting as a ribozyme to catalyze other biochemical...
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