Pancreatic elastase II (EC 3.4.21.71, pancreatic elastase 2) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction
Preferential cleavage: Leu-, Met- and Phe-. Hydrolyses elastin
This peptidase from trypsin family is formed by activation of proelastase II from mammalian pancreas by trypsin.
^Fletcher TS, Shen WF, Largman C (November 1987). "Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA". Biochemistry. 26 (23): 7256–61. doi:10.1021/bi00397a010. PMID 3427074.
^Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, Ozawa T, Mikayama T, Iijima H, Ishida A (December 1987). "Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2". Journal of Biochemistry. 102 (6): 1555–63. doi:10.1093/oxfordjournals.jbchem.a122204. PMID 2834346.
and 21 Related for: Pancreatic elastase II information
PancreaticelastaseII (EC 3.4.21.71, pancreaticelastase 2) is an enzyme. This enzyme catalyses the following chemical reaction Preferential cleavage:...
Pancreaticelastase is a form of elastase that is produced in the acinar cells of the pancreas, initially produced as an inactive zymogen and later activated...
Shimoda K, Takiguchi Y (April 1987). "Characterization of pancreaticelastaseII cDNAs: two elastaseII mRNAs are expressed in human pancreas". DNA. 6 (2):...
Shimoda K, Takiguchi Y (Jul 1987). "Characterization of pancreaticelastaseII cDNAs: two elastaseII mRNAs are expressed in human pancreas". DNA. 6 (2):...
states. In chronic pancreatitis, the fecal pancreaticelastase-1 (FPE-1) test is a marker of exocrine pancreatic function. Additional tests that may be useful...
Name ; Designation in the laboratory ; Laboratory) Pancreaticelastase;Feces-Pancreaticelastase;Clinical Biochemistry Laboratory ; Adenovirus DNA PCR;Adenovirus...
pancreatic elastase 1. However unlike other elastases, pancreaticelastase 1 is not expressed in the pancreas. Hence this enzyme has been renamed as elastase-1...
the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss...
seminal fluids. SLPI inhibits human leukocyte elastase, human cathepsin G, human trypsin, neutrophil elastase, and mast cell chymase. X-ray crystallography...
enzymes. The major proteases, the pancreatic enzymes which work on proteins, are trypsinogen and chymotrypsinogen. Elastase is also produced. Smaller amounts...
and named it elastase. This is now known to be only one of a class of peptidases capable of cleaving elastin, and the pancreaticelastase Banga and Baló...
Another example is depelestat, an inhibitor of neutrophil elastase that has undergone Phase II clinical trials for the treatment of acute respiratory distress...
Ladner RC (1978). "The atomic structure of crystalline porcine pancreaticelastase at 2.5Å resolution: comparison with the structure of alpha-chymotrypsin"...
elastase and porcine pancreaticelastase toward peptide 4-nitroanilides containing model desmosine residues. Evidence that human leukocyte elastase is...
the highest inhibition of proteolytic enzymes trypsin and porcine pancreaticelastase. Research suggests that the biosynthesis of both atranorin and physodic...
centred on a methionine in alpha1-antitrypsin as an inhibitor of tissue elastase and on arginine in antithrombin as an inhibitor of thrombin. The critical...
selectivity over other critical human proteases such as DPP-2, DPP-8, DPP-9, elastase, trypsin, urokinase and cathepsin G. The kinetics of DPP-4 inhibition by...
with those of proinflammatory mediators such as interleukin-6 (IL-6), elastase and tumor necrosis factor-α (TNF-α). During inflammation, the concentrations...
fragments have diverse biological properties. Nackman et al. demonstrated that elastase generated elastin fragments mediate several characteristic features of...
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