Pancreatic elastase is a form of elastase that is produced in the acinar cells of the pancreas, initially produced as an inactive zymogen and later activated in the duodenum by trypsin. Elastases form a subfamily of serine proteases, characterized by a distinctive structure consisting of two beta barrel domains converging at the active site that hydrolyze amides and esters amongst many proteins in addition to elastin, a type of connective tissue that holds organs together. Pancreatic elastase 1 is a serine endopeptidase, a specific type of protease that has the amino acid serine at its active site. Although the recommended name is pancreatic elastase, it can also be referred to as elastase-1, pancreatopeptidase, PE, or serine elastase.
The first isozyme, pancreatic elastase 1, was initially thought to be expressed in the pancreas. However it was later discovered that it was the only chymotrypsin-like elastase that was not expressed in the pancreas. In fact, pancreatic elastase is expressed in basal layers of epidermis (at protein level). Hence pancreatic elastase 1 has been renamed elastase 1 (ELA1) or chymotrypsin-like elastase family, member 1 (CELA1).[1] For a period of time, it was thought that ELA1 / CELA1 was not transcribed into a protein.[2] However it was later discovered that it was expressed in skin keratinocytes.[3]
Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B (CELA3B).[1]
^ abEntrezGene 1990
^Rose SD, MacDonald RJ (June 1997). "Evolutionary silencing of the human elastase I gene (ELA1)". Hum. Mol. Genet. 6 (6): 897–903. doi:10.1093/hmg/6.6.897. PMID 9175736.
^Talas U, Dunlop J, Khalaf S, Leigh IM, Kelsell DP (January 2000). "Human elastase 1: evidence for expression in the skin and the identification of a frequent frameshift polymorphism". J. Invest. Dermatol. 114 (1): 165–70. doi:10.1046/j.1523-1747.2000.00825.x. PMID 10620133.
and 28 Related for: Pancreatic elastase information
Pancreaticelastase is a form of elastase that is produced in the acinar cells of the pancreas, initially produced as an inactive zymogen and later activated...
collect pancreatic secretions. The fecal elastase test is a less cumbersome test that has replaced the 72-hour fecal fat test; in the fecal elastase test...
for elastase: Some bacteria (including Pseudomonas aeruginosa) also produce elastase. In bacteria, elastase is considered a virulence factor. Elastase breaks...
Pancreaticelastase II (EC 3.4.21.71, pancreaticelastase 2) is an enzyme. This enzyme catalyses the following chemical reaction Preferential cleavage:...
of pancreatic function in clinical assays. Fecal elastase is a medical test that measures how well the pancreas is functioning. The fecal elastase test...
states. In chronic pancreatitis, the fecal pancreaticelastase-1 (FPE-1) test is a marker of exocrine pancreatic function. Additional tests that may be useful...
digestive enzymes, including trypsinogen, chymotrypsinogen, elastase, carboxypeptidase, pancreatic lipase, nucleases and amylase. The pancreas is located in...
Shimoda K, Takiguchi Y (Jul 1987). "Characterization of pancreaticelastase II cDNAs: two elastase II mRNAs are expressed in human pancreas". DNA. 6 (2):...
amino acid group from a protein Several elastases that degrade the protein elastin and some other proteins Pancreatic lipase that degrades triglycerides into...
Elaszym may refer to one of two enzymes: Pancreaticelastase Neutrophil elastase This disambiguation page lists articles associated with the title Elaszym...
steatorrhoea is rarely performed nowadays. Low fecal pancreaticelastase is indicative of pancreatic insufficiency. Chymotrypsin and pancreolauryl can be...
Shimoda K, Takiguchi Y (April 1987). "Characterization of pancreaticelastase II cDNAs: two elastase II mRNAs are expressed in human pancreas". DNA. 6 (2):...
pancreatic elastase 1. However unlike other elastases, pancreaticelastase 1 is not expressed in the pancreas. Hence this enzyme has been renamed as elastase-1...
Y (1996). "Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreaticelastase determined at 1.9 A resolution". Biochemistry...
Takiguchi Y (Feb 1988). "Identification of a novel class of elastase isozyme, human pancreaticelastase III, by cDNA and genomic gene cloning". J Biol Chem....
the highest inhibition of proteolytic enzymes trypsin and porcine pancreaticelastase. Research suggests that the biosynthesis of both atranorin and physodic...
(13)C-mixed triglycerides test and fecal elastase, to detect possible fat maldigestion due to exocrine pancreatic insufficiency, or various specific tests...
and characterization of a nonelastolytic enzyme, protease E. resembling elastase". Biochemistry. 14 (4): 722–30. doi:10.1021/bi00675a012. PMID 234742. Shen...
known as pancreatogenic diabetes) is diabetes that comes secondary to pancreatic diseases, involving the exocrine and digestive functions of the pancreas...
elastase and porcine pancreaticelastase toward peptide 4-nitroanilides containing model desmosine residues. Evidence that human leukocyte elastase is...
Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins...
Ladner RC (1978). "The atomic structure of crystalline porcine pancreaticelastase at 2.5Å resolution: comparison with the structure of alpha-chymotrypsin"...
system, inhibit neutrophil elastase strongly while ecotin from the plant pathogen Pantoea citrea inhibits neutrophil elastase 1000-fold less potently. Ecotins...
malabsorption due to exocrine pancreatic insufficiency. Exocrine pancreatic insufficiency can be confirmed by also checking a fecal elastase level, with low levels...
and named it elastase. This is now known to be only one of a class of peptidases capable of cleaving elastin, and the pancreaticelastase Banga and Baló...
enzymes. The major proteases, the pancreatic enzymes which work on proteins, are trypsinogen and chymotrypsinogen. Elastase is also produced. Smaller amounts...
emphysema component of COPD may be induced in hamsters by injecting pancreaticelastase into their tracheas. Pulmonary fibrosis may be induced in hamsters...
Global Information