Kunitz domains are the active domains of proteins that inhibit the function of protein degrading enzymes or, more specifically, domains of Kunitz-type are protease inhibitors. They are relatively small with a length of about 50 to 60 amino acids and a molecular weight of 6 kDa. Examples of Kunitz-type protease inhibitors are aprotinin (bovine pancreatic trypsin inhibitor, BPTI), Alzheimer's amyloid precursor protein (APP), and tissue factor pathway inhibitor (TFPI). Kunitz STI protease inhibitor, the trypsin inhibitor initially studied by Moses Kunitz, was extracted from soybeans.
Standalone Kunitz domains are used as a framework for the development of new pharmaceutical drugs.[2]
^PDB: 1KTH; Arnoux B, Ducruix A, Prangé T (July 2002). "Anisotropic behaviour of the C-terminal Kunitz-type domain of the alpha3 chain of human type VI collagen at atomic resolution (0.9 Å)". Acta Crystallogr. D. 58 (Pt 7): 1252–4. doi:10.1107/S0907444902007333. PMID 12077460.
^Nixon, AE; Wood, CR (2006). "Engineered protein inhibitors of proteases". Current Opinion in Drug Discovery & Development. 9 (2): 261–8. PMID 16566296.
Kunitzdomains are the active domains of proteins that inhibit the function of protein degrading enzymes or, more specifically, domains of Kunitz-type...
Kunitz is the surname of several people: Chris Kunitz (born 1979), a Canadian professional ice hockey player Jaana Kunitz (Yaana Kunitz; born 1972), an...
amino-terminus, three tandemly linked Kunitzdomains, and a highly positively charged carboxy-terminus. With its Kunitzdomains, TFPI exhibits significant homology...
kallikrein and a 60-amino acid polypeptide which was developed from a Kunitzdomain through phage display to mimic antibodies inhibiting kallikrein. On...
consist of a high variety of putative toxins, including ShKT domain- and Kunitzdomain- containing proteins which are potential therapeutic compounds...
Kunitz-type protease inhibitor 1 is an enzyme that in humans is encoded by the SPINT1 gene. The protein encoded by this gene is a member of the Kunitz...
"Monobodies: antibody mimics based on the scaffold of the fibronectin type III domain". Protein Engineering Protocols. Methods Mol. Biol. Vol. 352. pp. 95–109...
carbohydrate chains are located between Kunitzdomains 2 and 3 and one N-linked carbohydrate chain is in Kunitzdomain 2". Biochemistry. 35 (20): 6450–9. doi:10...
signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitzdomains, and an NTR domain. These domains have been implicated...
Kunitz soybean trypsin inhibitor is a type of protein contained in legume seeds which functions as a protease inhibitor. Kunitz-type Soybean Trypsin Inhibitors...
Sprecher CA, Foster DC, et al. (1996). "Inhibitory properties of a novel human Kunitz-type protease inhibitor homologous to tissue factor pathway inhibitor"....
modes of action of SHTX I and II are currently unknown. SHTX III has a Kunitz-domain and therefore has a protease inhibitor. In sea anemones, it has been...
such as scorpions, snakes, spiders, and sea anemones. All Kunitz peptides share the Kunitzdomain, which is characterized by a peptide chain of approximately...
This article incorporates text from this source, which is in the public domain. Madelain V, Nguyen TH, Olivo A, et al. (August 2016). "Ebola Virus Infection:...
1971–1973: Josephine Jacobsen 1973–1974: Daniel Hoffman 1974–1976: Stanley Kunitz 1976–1978: Robert Hayden 1978–1980: William Meredith 1981–1982: Maxine Kumin...
Moses Kunitz (December 19, 1887 – April 20, 1978) was a Russian-American biochemist who spent most of his career at Rockefeller University. He is best...
SPINT2 gene. SPINT2 is a transmembrane protein with two extracellular Kunitzdomains to inhibit serine proteases. This gene is a presumed tumor suppressor...
follistatin domain, immunoglobulin domain, two tandem Kunitzdomains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization...
protein. The extracellular domain (residues 32-692) contains the E1 domain, E2 domain, and BPTI/Kunitz inhibitor domain. The E1 domain contains two independent...
of proteins known as dendrotoxins; although structurally homologous to Kunitz-type protease inhibitors, they block voltage-dependent potassium channels...
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