regulation of platelet-derived growth factor receptor-beta signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4015
16948
Ensembl
ENSG00000113083
ENSMUSG00000024529
UniProt
P28300
P28301
RefSeq (mRNA)
NM_002317 NM_001178102 NM_001317073
NM_010728 NM_001286181 NM_001286182
RefSeq (protein)
NP_001171573 NP_001304002 NP_002308
NP_001273110 NP_001273111 NP_034858
Location (UCSC)
Chr 5: 122.06 – 122.08 Mb
Chr 18: 52.65 – 52.66 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Not to be confused with Lipoxygenase.
Lysyl oxidase (LOX), also known as protein-lysine 6-oxidase, is an enzyme that, in humans, is encoded by the LOX gene.[5][6] It catalyzes the conversion of lysine residues into its aldehyde derivative allysine.[7] Allysine form cross-links in extracellular matrix proteins. Inhibition of lysyl oxidase can cause osteolathyrism, but, at the same time, its upregulation by tumor cells may promote metastasis of the existing tumor, causing it to become malignant and cancerous.
^ abcGRCh38: Ensembl release 89: ENSG00000113083 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024529 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: LOX lysyl oxidase".
^Hämäläinen ER, Jones TA, Sheer D, Taskinen K, Pihlajaniemi T, Kivirikko KI (Nov 1991). "Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2". Genomics. 11 (3): 508–16. doi:10.1016/0888-7543(91)90057-L. PMID 1685472.
^Requena JR, Levine RL, Stadtman ER (2003). "Recent Advances in the Analysis of Oxidized Proteins". Amino Acids. 25 (3–4): 221–226. doi:10.1007/s00726-003-0012-1. PMID 14661085. S2CID 28837698.
Lysyloxidase (LOX), also known as protein-lysine 6-oxidase, is an enzyme that, in humans, is encoded by the LOX gene. It catalyzes the conversion of...
PMID 22159251. Mäki J (2002). Lysyloxidases : cloning and characterization of the fourth and the fifth human lysyloxidase isoenzymes, and the consequences...
extensive crosslinking by members of the lysyloxidase and lysyloxidase like family of copper-dependent amine oxidases into amorphous elastin, a highly resilient...
Lysyloxidase homolog 1, also known as LOXL1, is an enzyme which in humans is encoded by the LOXL1 gene. This gene encodes a member of the lysyl oxidase...
III, a type of fibrillar collagen. Formation of the collagen fibril: lysyloxidase, an extracellular copper-dependent enzyme, produces the final step in...
cytochrome c oxidase, which is complex IV in the mitochondrial electron transport chain, ceruloplasmin, Cu/Zn superoxide dismutase, and in amine oxidases. These...
Lysyloxidase homolog 2 is an enzyme that in humans is encoded by the LOXL2 gene. This gene encodes a member of the lysyloxidase gene family. The prototypic...
Lysyloxidase homolog 4 is an enzyme that in humans is encoded by the LOXL4 gene. This gene encodes a member of the lysyloxidase gene family. The prototypic...
beta-aminopropionitrile that prevents the cross-linking of collagen by inhibiting lysyloxidase and thus the formation of allysine, leading to loose skin. Recent experiments...
cross-linking molecules. The enzyme that performs the crosslinking is lysyloxidase, using an in vivo Chichibabin pyridine synthesis reaction. In mammals...
c oxidase activity. The brittle, kinky hypopigmented hair of steely appearance is due to a deficiency in an unidentified cuproenzyme. Reduced lysyl oxidase...
in collagen and elastin are derived from lysyl and hydroxylysyl residues, a process catalyzed by lysyloxidase. Fujimoto and colleagues first described...
Lysyloxidase homolog 3 is an enzyme that in humans is encoded by the LOXL3 gene. This gene encodes a member of the lysyloxidase gene family. The prototypic...
beta-aminopropionitrile, which inhibits the copper-containing enzyme lysyloxidase, responsible for cross-linking procollagen and proelastin. BAPN is also...
by the reaction of ammonia with acrylonitrile. Kashin-Beck disease Lysyloxidase Marfan syndrome "Aminopropionitrile - Compound Summary". PubChem Compound...
function of bone, skin, hair, blood vessels and the nervous system such as lysyloxidase. As with other X-linked disorders, female children of a carrier mother...
prosthetic Cu(II)-bipyridine cofactor complex in the enzyme lysyloxidase. Lysyloxidase is an important enzyme for the creation of crosslinks between...
many copper enzymes (often to 50% of their total potential), including lysyloxidase, an enzyme that cross-links collagen and elastin. Especially valuable...
collagen molecules associate with their neighbors and crosslink via lysyloxidase to form collagen fibrils. At this stage, they are not yet mineralized...
caused by the toxin BAPN, which inhibits the copper-containing enzyme lysyloxidase, responsible for cross-linking tropocollagen and proelastin. BAPN is...
dopamine. VAP-1 constitutes the copper dependent class of amine oxidases, such as lysyloxidase or lysine demethylase, and is one of the four known in humans...
1922;69:732-734. Schlötzer-Schrehardt, U., & Zenkel, M. (2019). The role of lysyloxidase-like 1 (LOXL1) in exfoliation syndrome and glaucoma. Experimental eye...
It is produced by aerobic oxidation of lysine residues by the enzyme lysyloxidase. The transformation is an example of a post-translational modification...
the condensation of four lysine residues between elastin proteins by lysyl-oxidase. These represent ideal biomarkers for monitoring elastin turnover because...
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