Database of protein domains, families and functional sites
PROSITE
Content
Description
PROSITE, a protein domain database for functional characterization and annotation.
Contact
Research center
Swiss Institute of Bioinformatics
Laboratory
Structural Biology and Bioinformatics Department
Primary citation
PMID 19858104
Release date
1988 (1988)
Access
Website
prosite.expasy.org
PROSITE is a protein database.[1][2] It consists of entries describing the protein families, domains and functional sites as well as amino acid patterns and profiles in them. These are manually curated by a team of the Swiss Institute of Bioinformatics and tightly integrated into Swiss-Prot protein annotation. PROSITE was created in 1988 by Amos Bairoch, who directed the group for more than 20 years. Since July 2018, the director of PROSITE and Swiss-Prot is Alan Bridge.
PROSITE's uses include identifying possible functions of newly discovered proteins and analysis of known proteins for previously undetermined activity. Properties from well-studied genes can be propagated to biologically related organisms, and for different or poorly known genes biochemical functions can be predicted from similarities. PROSITE offers tools for protein sequence analysis and motif detection (see sequence motif, PROSITE patterns). It is part of the ExPASy proteomics analysis servers.
The database ProRule builds on the domain descriptions of PROSITE.[3] It provides additional information about functionally or structurally critical amino acids. The rules contain information about biologically meaningful residues, like active sites, substrate- or co-factor-binding sites, posttranslational modification sites or disulfide bonds, to help function determination. These can automatically generate annotation based on PROSITE motifs.
^De Castro E, Sigrist CJA, Gattiker A, Bulliard V, Langendijk-Genevaux PS, Gasteiger E, Bairoch A, Hulo N (2006). "ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins". Nucleic Acids Res. 34 (Web Server issue): W362–365. doi:10.1093/nar/gkl124. PMC 1538847. PMID 16845026.
^Hulo N, Bairoch A, Bulliard V, Cerutti L, Cuche B, De Castro E, Lachaize C, Langendijk-Genevaux PS, Sigrist CJA (2007). "The 20 years of PROSITE". Nucleic Acids Res. 36 (Database issue): D245–9. doi:10.1093/nar/gkm977. PMC 2238851. PMID 18003654.
^Sigrist CJ, De Castro E, Langendijk-Genevaux PS, Le Saux V, Bairoch A, Hulo N (2005). "ProRule: a new database containing functional and structural information on PROSITE profiles". Bioinformatics. 21 (21): 4060–4066. doi:10.1093/bioinformatics/bti614. PMID 16091411.
PROSITE is a protein database. It consists of entries describing the protein families, domains and functional sites as well as amino acid patterns and...
elements. One of these notations is the PROSITE notation, described in the following subsection. The PROSITE notation uses the IUPAC one-letter codes...
flanking residues are highly conserved in known P450s, and have the formal PROSITE signature consensus pattern [FW] - [SGNH] - x - [GD] - {F} - [RKHPT] -...
invertebrates hints at ancient origin of this superfamily in evolution. The PROSITE pattern of this superfamily is located in a beta sheet in the central section...
unit from the hemocyanin of an octopus Identifiers Symbol Hemocyanin_M Pfam PF00372 InterPro IPR000896 PROSITE PDOC00184 SCOP2 1lla / SCOPe / SUPFAM...
DeviantArt and Saatchi's digital community. Adobe Portfolio (formerly ProSite) is Behance's DIY web design application, similar to popular tools such...
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