Tyrosinase is an oxidase that is the rate-limiting enzyme for controlling the production of melanin. The enzyme is mainly involved in two distinct reactions of melanin synthesis otherwise known as the Raper Mason pathway. Firstly, the hydroxylation of a monophenol and secondly, the conversion of an o-diphenol to the corresponding o-quinone. o-Quinone undergoes several reactions to eventually form melanin.[5] Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation. It is found inside melanosomes which are synthesized in the skin melanocytes. In humans, the tyrosinase enzyme is encoded by the TYR gene.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000077498 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000004651 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kumar CM, Sathisha UV, Dharmesh S, Rao AG, Singh SA (Mar 2011). "Interaction of sesamol (3,4-methylenedioxyphenol) with tyrosinase and its effect on melanin synthesis". Biochimie. 93 (3): 562–9. doi:10.1016/j.biochi.2010.11.014. PMID 21144881.
^Barton DE, Kwon BS, Francke U (Jul 1988). "Human tyrosinase gene, mapped to chromosome 11 (q14----q21), defines second region of homology with mouse chromosome 7". Genomics. 3 (1): 17–24. doi:10.1016/0888-7543(88)90153-X. PMID 3146546.
Tyrosinase is an oxidase that is the rate-limiting enzyme for controlling the production of melanin. The enzyme is mainly involved in two distinct reactions...
Tyrosinase-related protein 1, also known as TYRP1, is an intermembrane enzyme which in humans is encoded by the TYRP1 gene. Tyrp1 is a melanocyte-specific...
complex process involving the enzyme tyrosinase. Mammals have a gene that codes for the presence of tyrosinase in cells – called the TYR gene. If this...
"Oculocutaneous albinism type 1B associated with a functionally significant tyrosinase gene polymorphism detected with Whole Exome Sequencing". Ophthalmic Genetics...
of tyrosinase: The catalytic action of tyrosinase is inhibited by the skin whitening agent. Inhibition of the expression or activation of tyrosinase: The...
oculocutaneous albinism that is caused by a dysfunction in the gene for tyrosinase (symbol TYR or OCA1). The location of OCA1 may be written as "11q1.4–q2...
hyperpigmentation issues. Its mechanism of action involves inhibiting the activity of tyrosinase, an essential enzyme for melanin synthesis in the human skin, thereby...
action of PPOs to form o-quinone. Hence, PPOs may also be referred to as tyrosinases. Common foods producing the enzyme include mushrooms (Agaricus bisporus)...
all vertebrates, including humans. It is due to absence or defect of tyrosinase, a copper-containing enzyme involved in the production of melanin. Unlike...
is a form of partial albinism resulting from a mutation that affects tyrosinase, an enzyme involved with melanin production. The mutated enzyme is thermolabile;...
being a component of a number of hair and skin conditioners. AzA inhibits tyrosinase. Azelaic acid is industrially produced by the ozonolysis of oleic acid...
regulated by the microphthalmia-associated transcription factor (MITF). Tyrosinase-related protein 1 (TYRP1) Dopachrome, a cyclization product of L-DOPA...
albinism, resulting from a mutation in tyrosinase, an enzyme involved in melanin production. The mutated tyrosinase enzyme is heat-sensitive; it fails to...
(dipteran) hexamerin receptors. Phenoloxidase are copper containing tyrosinases. These proteins are involved in the process of sclerotization of arthropod...
organelles called melanosomes. This reaction is catalyzed by the enzyme tyrosinase. The initial product, dopaquinone can transform into either 5,6-dihydroxyindole...
pigments called melanins, commonly associated with a genetic loss of tyrosinase function. Amelanism can affect fish, amphibians, reptiles, birds, and...
melanin, removing all black pigmentation. However, they are believed to be tyrosinase-positive (hence the T+), and therefore can still create some darker pigments...
example of such a protein is the enzyme tyrosinase, which is required for melanin production. Normally tyrosinase is produced in minute quantities but its...
Studies have shown that the reduced pigment comes from a mutation in the gene for tyrosinase, the same as causes Type I oculocutaneous albinism in humans....
pattern [1] is a form of partial albinism, resulting from a mutation in tyrosinase, an enzyme involved in melanin production. The mutated enzyme is heat-sensitive;...
OCA1A, which impairs tyrosinase production. In other mammals, the diagnosis of albinism is based on the impairment of tyrosinase production through defects...
Tyrosinemia type II is an autosomal recessive condition with onset between ages 2 and 4 years, when painful circumscribed calluses develop on the pressure...
a mouse model of hyperoxaluria. Tiliroside from raspberry is a potent tyrosinase inhibitor and might be used as a skin-whitening agent and pigmentation...
an albino phenotype may be caused by a mutation in the gene encoding tyrosinase which is a key enzyme in melanin formation. However, exposure to UV radiation...
is often but not always related to the TYR gene coding the tyrosinase enzyme. Tyrosinase is required for melanocytes to produce melanin from the amino...
He wrote a dissertation on "Kinetics of the Reaction Inactivation of Tyrosinase During Its Catalysis of the Aerobic Oxidation of Catechol". An abridged...
on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression". Pigment Cell Research. 19 (1): 90–8. doi:10.1111/j.1600-0749...
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