positive regulation of hemoglobin biosynthetic process
histone H4-R3 methylation
positive regulation of erythrocyte differentiation
negative regulation of megakaryocyte differentiation
cell surface receptor signaling pathway
methylation
peptidyl-arginine methylation
histone methylation
neuron projection development
peptidyl-arginine N-methylation
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
regulation of transcription, DNA-templated
protein methylation
positive regulation of cell population proliferation
regulation of megakaryocyte differentiation
in utero embryonic development
histone arginine methylation
protein homooligomerization
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3276
15469
Ensembl
ENSG00000126457
ENSMUSG00000109324
UniProt
Q99873
Q9JIF0
RefSeq (mRNA)
NM_001207042 NM_001536 NM_198318 NM_198319
NM_001252476 NM_001252477 NM_019830
RefSeq (protein)
NP_001193971 NP_001527 NP_938074
NP_001239405 NP_001239406 NP_062804
Location (UCSC)
Chr 19: 49.68 – 49.69 Mb
Chr 7: 44.63 – 44.64 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Protein arginine N-methyltransferase 1 is an enzyme that in humans is encoded by the PRMT1 gene.[5] The HRMT1L2 gene encodes a protein arginine methyltransferase that functions as a histone methyltransferase specific for histone H4.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000126457 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000109324 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Scott HS, Antonarakis SE, Lalioti MD, Rossier C, Silver PA, Henry MF (June 1998). "Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)". Genomics. 48 (3): 330–40. doi:10.1006/geno.1997.5190. PMID 9545638.
^"Entrez Gene: PRMT1 protein arginine methyltransferase 1".
arginine N-methyltransferase 1 is an enzyme that in humans is encoded by the PRMT1 gene. The HRMT1L2 gene encodes a protein arginine methyltransferase that...
Chromatin target of PRMT1 is a protein that in humans is encoded by the CHTOP gene. This gene encodes a small nuclear protein that is characterized by...
methyltransferase 1 (PRMT1) was found to be associated with changes in transcription due to the methyltransferase function of PRMT1. Overexpression causes...
"PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity...
H4 by PRMT1 was sufficient to permit subsequent acetylation on the N-terminal tail. However, acetylation of H4 inhibits its methylation by PRMT1. Acetylation...
An W, Kim J, Roeder RG (June 2004). "Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53". Cell. 117 (6): 735–48...
can occur at arginine residues on histone tails. The first type of PRMTs (PRMT1, PRMT3, CARM1⧸PRMT4, and Rmt1⧸Hmt1) produce monomethylarginine and asymmetric...
Xie M, Zhang H, et al. (January 2020). "UBAP2L arginine methylation by PRMT1 modulates stress granule assembly". Cell Death and Differentiation. 27 (1):...
different classes of protein arginine methyltransferases (PRMTs): Type I PRMTs (PRMT1, PRMT2, PRMT3, PRMT4, PRMT6, and PRMT8) attach two methyl groups to a single...
target for medulloblastoma therapy. BTG2 has been shown to interact with PRMT1, HOXB9, CNOT8 and HDAC1 HDAC4 and HDAC9. It has also been studied with Pax6...
proliferation. BTG1 has been shown to interact with: CNOT7, CNOT8, HOXB9, and PRMT1. Recurrent mutations in this gene have been associated to cases of diffuse...
protein is arginine methylated by protein arginine methyltransferase 1 (PRMT1) at residues R95 and R177. Type I PRMT inhibitor (MS023) or substitution...
Passos DO; Bressan GC; Nery FC; Kobarg J (2006). "Ki-1/57 interacts with PRMT1 and is a substrate for arginine methylation". FEBS J. 273 (17): 3946–61...
An W, Kim J, Roeder RG (June 2004). "Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53". Cell. 117 (6): 735–48...
number of regulators in epidermal homeostasis, including ZNF750, MAF, MAFB, PRMT1, CSNK1A1, EHF, MPZL3, FDXR, TINCR, and ACTL6A. It uncovered new regulators...
citing yeast two-hybrid screenings have found C20orf196 to interact with PRMT1, QARS, MAD2L2, and CUL3. C20orf196 functionally interacts with REV7, SHLD2...
Y, Ponder BA, Nakamura Y, Hamamoto R (February 2011). "Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types...
protein II and in vitro methylation by protein arginine methyltransferases PRMT1 and PRMT3". J. Biol. Chem. 274 (19): 13229–34. doi:10.1074/jbc.274.19.13229...
MC, Corbo L, Le Romancer M (February 2007). "hCAF1, a new regulator of PRMT1-dependent arginine methylation". J. Cell Sci. 120 (Pt 4): 638–47. doi:10...
HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene". Mamm. Genome. 8 (7): 526–9. doi:10.1007/s003359900491. PMID 9196002...
PC4 and Mediator cofactors. HNRNPR has been shown to interact with SMN1, PRMT1, TDP-43, and FUS/TLS. ENSG00000125944 GRCh38: Ensembl release 89: ENSG00000282958...
Global Information
