One of the five main histone proteins involved in the structure of chromatin
H4 histone, family 3
Identifiers
Symbol
H4F3
NCBI gene
3023
HGNC
4780
UniProt
P62805
Other data
Locus
Chr. 3 q13.13
Search for
Structures
Swiss-model
Domains
InterPro
Basic units of chromatin structure
Histone H4 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H4 is involved with the structure of the nucleosome of the 'beads on a string' organization. Histone proteins are highly post-translationally modified. Covalently bonded modifications include acetylation and methylation of the N-terminal tails. These modifications may alter expression of genes located on DNA associated with its parent histone octamer.[1][2] Histone H4 is an important protein in the structure and function of chromatin, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes.
^Bhasin M, Reinherz EL, Reche PA (2006). "Recognition and classification of histones using support vector machine" (PDF). Journal of Computational Biology. 13 (1): 102–112. doi:10.1089/cmb.2006.13.102. PMID 16472024.
^Hartl DL, Freifelder D, Snyder LA (1988). Basic Genetics. Boston: Jones and Bartlett Publishers. ISBN 978-0-86720-090-4.
HistoneH4 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a...
designated H1/H5 (linker histones), H2, H3, and H4 (core histones). The nucleosome core is formed of two H2A-H2B dimers and a H3-H4 tetramer. The tight wrapping...
called histones, which are known as a histone octamer. Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4. DNA...
most of the cytoplasmic HAT activity in yeast, and it binds strongly to histoneH4 by virtue of its association with an additional subunit, Hat2. Elp3 is...
the DNA packaging protein histoneH4. It is a mark that indicates the acetylation at the 5th lysine residue of the histoneH4 protein. H4K5 is the closest...
the DNA packaging protein HistoneH4. It is a mark that indicates the acetylation at the 16th lysine residue of the histoneH4 protein. H4K16ac is unusual...
the DNA packaging protein histoneH4. It is a mark that indicates the acetylation at the 12th lysine residue of the histoneH4 protein. H4K12ac is involved...
acetylates nucleosomal histoneH4 have been reported. NuA4 has an apparent molecular mass of 1.3 MDa. All four conserved lysines of histoneH4 can be acetylated...
DNA packaging protein HistoneH4. It is a mark that indicates the mono-methylation at the 20th lysine residue of the histoneH4 protein. This mark can...
The histone code is a hypothesis that the transcription of genetic information encoded in DNA is in part regulated by chemical modifications (known as...
Histone variants are proteins that substitute for the core canonical histones (H3, H4, H2A, H2B) in nucleosomes in eukaryotes and often confer specific...
the four core histone proteins (H2A, H2B, H3, and H4). The octamer assembles when a tetramer, containing two copies of H3 and two of H4, complexes with...
to the DNA packaging protein histoneH4, is a mark indicating the acetylation at the 8th lysine residue of the histoneH4 protein. It has been implicated...
the DNA packaging protein histoneH4. It is a mark that indicates the acetylation at the 91st lysine residue of the histoneH4 protein. No known diseases...
protein complexes called histone cores. These histone cores are composed of 8 subunits, two each of H2A, H2B, H3 and H4histones. This protein complex forms...
other histone proteins are: H1, H2B, H3 and H4. Histones are proteins that package DNA into nucleosomes. Histones are responsible for maintaining the shape...
a human gene HistoneH4, a protein involved in the structure of chromatin in eukaryotic cells Hydrogen-4 (H-4), an isotope of hydrogen H4, a symmetry group...
enhance global histoneH4 acetylation, which requires intact PHD2 finger. Similarly to HBO1, JADE1 is responsible for bulk histoneH4 acetylation in cultured...
components of chromatin are histones. An octamer of two sets of four histone cores (Histone H2A, Histone H2B, Histone H3, and HistoneH4) bind to DNA and function...
HistoneH4 is a protein that in humans is encoded by the HIST1H4C gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure...
HistoneH4 is a protein that in humans is encoded by the HIST1H4E gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure...
be found in the archaeal histones, which could have come from eukaryotic H3-H4 tetramer. The archaeal single-chain histones are also found in the bacterium...
HistoneH4 is a protein that in humans is encoded by the HIST1H4K gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure...
histone-DNA interactions. Two copies of histone H2B come together with two copies each of histone H2A, histone H3, and histoneH4 to form the octamer core of the...
HistoneH4 is a protein that in humans is encoded by the HIST2H4A gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure...
HistoneH4 is a protein that in humans is encoded by the HIST1H4H gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure...
as a histone methyltransferase specific for histoneH4. PRMT1 gene encodes for the protein arginine methyltransferase that functions as a histone methyltransferase...
HistoneH4 is a protein that, in humans, is encoded by the HIST1H4I gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure...
HistoneH4 is a protein that in humans is encoded by the HIST1H4D gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure...
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