positive regulation of transcription, DNA-templated
heart development
regulation of transcription from RNA polymerase II promoter in response to hypoxia
viral process
protein acetylation
Notch signaling pathway
cellular response to UV
protein stabilization
positive regulation of DNA-binding transcription factor activity
negative regulation of transcription by RNA polymerase II
nervous system development
regulation of autophagy
regulation of androgen receptor signaling pathway
positive regulation of protein binding
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
fat cell differentiation
positive regulation by host of viral transcription
megakaryocyte development
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
internal protein amino acid acetylation
regulation of cell cycle
regulation of tubulin deacetylation
positive regulation of gene expression
histone H4 acetylation
regulation of cellular response to heat
transcription-coupled nucleotide-excision repair
skeletal muscle tissue development
positive regulation of type I interferon production
response to estrogen
response to hypoxia
regulation of signal transduction by p53 class mediator
internal peptidyl-lysine acetylation
beta-catenin-TCF complex assembly
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
macrophage derived foam cell differentiation
circadian rhythm
protein deubiquitination
positive regulation of transcription by RNA polymerase II
protein destabilization
regulation of megakaryocyte differentiation
histone acetylation
epigenetic maintenance of chromatin in transcription-competent conformation
peptidyl-lysine propionylation
peptidyl-lysine crotonylation
peptidyl-lysine butyrylation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2033
328572
Ensembl
ENSG00000100393
ENSMUSG00000055024
UniProt
Q09472
B2RWS6
RefSeq (mRNA)
NM_001429 NM_001362843
NM_177821
RefSeq (protein)
NP_001420 NP_001349772
NP_808489
Location (UCSC)
Chr 22: 41.09 – 41.18 Mb
Chr 15: 81.47 – 81.54 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene.[5] It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap DNA less tightly. This enzyme plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. The p300 protein appears to be critical for normal development before and after birth.
The EP300 gene is located on the long (q) arm of the human chromosome 22 at position 13.2. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein.
EP300 is closely related to another gene, CREB binding protein, which is found on human chromosome 16.
^ abcGRCh38: Ensembl release 89: ENSG00000100393 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000055024 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Eckner R, Ewen ME, Newsome D, Gerdes M, DeCaprio JA, Lawrence JB, Livingston DM (April 1994). "Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor". Genes Dev. 8 (8): 869–84. doi:10.1101/gad.8.8.869. PMID 7523245.
adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase...
EP300 antisense RNA 1 is a protein that in humans is encoded by the EP300-AS1 gene. "Human PubMed Reference:". National Center for Biotechnology Information...
long non-coding RNA DGCR6: DiGeorge syndrome critical region gene 6 EP300EP300-AS1 EWSR1 TAFA5: family with sequence similarity 19 member A5 FAM227A:...
possibly by inhibiting cytosolic autophagy-related protein acetylation by EP300 and thereby increasing acetylation of tubulin. Spermidine is known to regulate...
Penicillin binding proteins Retinol binding protein Retinol binding protein 4 EP300 Binding immunoglobulin protein Odorant binding protein Lipopolysaccharide-binding...
EP300-interacting inhibitor of differentiation 1 is a protein that in humans is encoded by the EID1 gene. EID1 has been shown to interact with EP300 and...
EP300 interacting inhibitor of differentiation 2, also known as EID2 is a human gene. The protein encoded by this gene may function as an endogenous suppressor...
Rubinstein-Taybi syndrome due to CREBBP mutations Rubinstein-Taybi syndrome due to EP300 haploinsufficiency Schwartz-Jampel syndrome type 1 Seckel syndrome 1, 2...
business was acquired by Lattice Semiconductor in 1999. Altera introduced the EP300 (first CMOS PAL) in 1983 and later moved into the FPGA business. Lattice...
Finally, BCL6’s interaction with other mutated proteins, including CREBBP, EP300, EZH2, and KM2TD, can also lead to B-cell lymphomas. Given its role as a...
on. EGR-1 has been shown to interact with: CEBPB, CREB-binding protein, EP300, NAB1, P53, and PSMA3 Zinc finger GRCh38: Ensembl release 89: ENSG00000120738...
Lineage Leukemia, KMT2A). The paralogous coactivators CBP (CREBBP) and P300 (EP300) are recruited to DNA-bound transcription factors to activate transcription...
of cases one or more of various other genes such as MLL2, SIN3A, ARID1A, EP300, CREBBP, and TBL1XR1) that have chromatin remodeling activity to thereby...
proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting...
neural evoked potential component of the electroencephalogram (EEG) p300 (or EP300), a transcriptional coactivator Nikon P300, a mid-class compact digital...
proliferation, and, in ≤15% of cases several other genes including MEF2B, STAT6, EP300, ARID1A, SLC22A2, CARD11, FOXO1, GNA12, B2M (i.e. the gene for beta-2 microglobulin)...
capacity for metastasis. STAT3 has been shown to interact with: AR, ELP2, EP300, EGFR, HIF1A, JAK1, JUN KHDRBS1, mTOR, MYOD1, NDUFA13, NFKB1, NR3C1, NCOA1...
Global Information
