PABPN1 information

PABPN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3B4D, 3B4M, 3UCG
Identifiers
Aliases	PABPN1, OPMD, PAB2, PABII, PABP-2, PABP2, poly(A) binding protein nuclear 1
External IDs	OMIM: 602279 MGI: 1859158 HomoloGene: 3412 GeneCards: PABPN1
Gene location (Human)
Chr.	Chromosome 14 (human)
End	23,326,163 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,135,626 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; anterior pituitary; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; ganglionic eminence; ; sural nerve; ; left uterine tube; ; stromal cell of endometrium; ; canal of the cervix; ; body of stomach;
	Top expressed in
	renal corpuscle; ; superior frontal gyrus; ; lip; ; cerebellar cortex; ; yolk sac; ; medullary collecting duct; ; olfactory bulb; ; entorhinal cortex; ; thymus; ; neural tube;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; RNA binding; RNA polymerase binding;
Cellular component	cytoplasm; nucleoplasm; nuclear inclusion body; nucleus; nuclear speck; ribonucleoprotein complex;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; RNA processing; muscle contraction; mRNA processing; poly(A)+ mRNA export from nucleus; modification by virus of host mRNA processing; mRNA 3'-end processing; MAPK cascade; cellular response to lipopolysaccharide; positive regulation of polynucleotide adenylyltransferase activity;
	Sources:Amigo / QuickGO
Orthologs
	8106
	54196
	ENSG00000100836
	ENSMUSG00000022194
	Q86U42
	Q8CCS6
	NM_004643; NM_001360551; NM_001360552
	NM_019402
	NP_004634; NP_001347480; NP_001347481
	NP_062275
	Wikidata
View/Edit Human	View/Edit Mouse

Polyadenylate-binding protein 2 (PABP-2) also known as polyadenylate-binding nuclear protein 1 (PABPN1) is a protein that in humans is encoded by the PABPN1 gene.^[5]^[6] PABN1 is a member of a larger family of poly(A)-binding proteins in the human genome.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100836 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022194 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brais B, Xie YG, Sanson M, Morgan K, Weissenbach J, Korczyn AD, Blumen SC, Fardeau M, Tomé FM, Bouchard JP (Aug 1995). "The oculopharyngeal muscular dystrophy locus maps to the region of the cardiac alpha and beta myosin heavy chain genes on chromosome 14q11.2-q13". Hum Mol Genet. 4 (3): 429–34. doi:10.1093/hmg/4.3.429. PMID 7795598.
^ "Entrez Gene: PABPN1 poly(A) binding protein, nuclear 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100836 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022194 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7795598-5] Brais B, Xie YG, Sanson M, Morgan K, Weissenbach J, Korczyn AD, Blumen SC, Fardeau M, Tomé FM, Bouchard JP (Aug 1995). "The oculopharyngeal muscular dystrophy locus maps to the region of the cardiac alpha and beta myosin heavy chain genes on chromosome 14q11.2-q13". Hum Mol Genet. 4 (3): 429–34. doi:10.1093/hmg/4.3.429. PMID 7795598.

[entrez-6] "Entrez Gene: PABPN1 poly(A) binding protein, nuclear 1".

PABPN1 information

and 11 Related for: PABPN1 information

PABPN1

Oculopharyngeal muscular dystrophy

Muscular dystrophy

Medical genetics of Jews

Housekeeping gene

PABPC1

RNA recognition motif

PABPII

SNW1

List of OMIM disorder codes

SLC46A3