cellular response to epidermal growth factor stimulus
regulation of chaperone-mediated autophagy
protein biosynthesis
protein methylation
neutrophil degranulation
regulation of D-erythro-sphingosine kinase activity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1915
13627
Ensembl
ENSG00000156508
ENSMUSG00000037742
UniProt
P68104
P10126
RefSeq (mRNA)
NM_001402 NM_001403
NM_010106
RefSeq (protein)
NP_001393
NP_034236
Location (UCSC)
Chr 6: 73.49 – 73.53 Mb
Chr 9: 78.39 – 78.4 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Elongation factor 1-alpha 1 (eEF1a1) is a translation elongation protein, expressed across eukaryotes. In humans, it is encoded by the EEF1A1 gene.[5][6]
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty's syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000156508 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037742 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lund A, Knudsen SM, Vissing H, Clark B, Tommerup N (Sep 1996). "Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3". Genomics. 36 (2): 359–61. doi:10.1006/geno.1996.0475. PMID 8812466.
^Wende H, Volz A, Ziegler A (Jul 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.
Elongationfactor1-alpha1 (eEF1a1) is a translationelongation protein, expressed across eukaryotes. In humans, it is encoded by the EEF1A1 gene. This...
sheet against two alpha helices. The prokaryotic initiation factors IF1 and IF2 are also homologs of the eukaryotic initiation factors eIF1A and eIF5B....
Eukaryotictranslationelongationfactor1alpha1 pseudogene 43 (eEF1A3) is a protein that in humans is encoded by the EEF1A1P43 gene. eEF-1 "Human PubMed...
Eukaryotic Initiation Factor 2 (eIF2) is an eukaryotic initiation factor. It is required for most forms of eukaryotictranslation initiation. eIF2 mediates...
homologous to archaeal transcription factor B and to eukaryoticfactor TFIIB. The specific sigma factor used to initiate transcription of a given gene will...
Eukaryotictranslation initiation factor 4E, also known as eIF4E, is a protein that in humans is encoded by the EIF4E gene. Most eukaryotic cellular mRNAs...
protein level it seems to resemble eukaryotictranslation. Most of the initiation, elongation, and termination factors in archaea have homologs in eukaryotes...
enzymology, an elongationfactor 2 kinase (EC 2.7.11.20) is an enzyme that catalyzes the chemical reaction: ATP + [elongationfactor 2] ⇌ {\displaystyle...
(November 2010). "Omnipotent role of archaeal elongationfactor1alpha (EF1α in translational elongation and termination, and quality control of protein...
Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ubiquitously. It was discovered in 1975 by...
the translationfactor G proteins. They play roles in translation, signal transduction, and cell motility. Multiple classical translationfactor family...
promoter is the first step in initiation. Once the σ-factor releases from the polymerase, elongation proceeds. The polymerase continues down the double...
also guides the nucleotides into position, facilitates attachment and elongation, has intrinsic proofreading and replacement capabilities, and termination...
"List Of All Transcription Factors In Human". biostars.org. Gill G (2001). "Regulation of the initiation of eukaryotic transcription". Essays in Biochemistry...
Elongationfactor1-alpha 2 is a protein that in humans is encoded by the EEF1A2 gene. This gene encodes an isoform of the alpha subunit of the elongation...
Eukaryotictranslation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme...
on whether or not the transcription elongation complex, itself consisting of a variety of transcription factors, can induce RNA polymerase to dissociate...
Eukaryotictranslation initiation factor 2-alpha kinase 1 is an enzyme that in humans is encoded by the EIF2AK1 gene. EIF2AK1 inhibits protein synthesis...
double-stranded RNA-activated protein kinase, or eukaryotictranslation initiation factor 2-alpha kinase 2 (EIF2AK2) is an enzyme that in humans is encoded...
(SASP). Interleukin 1alpha (IL1A) is found on the surface of senescent cells where it contributes to the production of SASP factors due to a positive feedback...
Eukaryotictranslation initiation factor 2A (eIF2A) is a protein that in humans is encoded by the EIF2A gene. The eIF2A protein is not to be confused with...
Global Information
