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Dipyridamole information


Dipyridamole
Clinical data
Trade namesPersantine, others
AHFS/Drugs.comMonograph
MedlinePlusa682830
Routes of
administration
By mouth, intravenous
ATC code
  • B01AC07 (WHO)
Legal status
Legal status
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Bioavailability37–66%[1]
Protein binding~99%
MetabolismLiver (glucuronidation)[2]
Elimination half-lifeα phase: 40 min,
β phase: 10 hours
ExcretionBiliary (95%), urine (negligible)
Identifiers
IUPAC name
  • 2,2',2'',2'''-(4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl)bis(azanetriyl)tetraethanol
CAS Number
  • 58-32-2 checkY
PubChem CID
  • 3108
IUPHAR/BPS
  • 4807
DrugBank
  • DB00975 checkY
ChemSpider
  • 2997 checkY
UNII
  • 64ALC7F90C
KEGG
  • D00302 checkY
ChEBI
  • CHEBI:4653 checkY
ChEMBL
  • ChEMBL932 checkY
CompTox Dashboard (EPA)
  • DTXSID6040668 Edit this at Wikidata
ECHA InfoCard100.000.340 Edit this at Wikidata
Chemical and physical data
FormulaC24H40N8O4
Molar mass504.636 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • C1CCN(CC1)C2=NC(=NC3=C2N=C(N=C3N4CCCCC4)N(CCO)CCO)N(CCO)CCO
InChI
  • InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 checkY
  • Key:IZEKFCXSFNUWAM-UHFFFAOYSA-N checkY
  (verify)

Dipyridamole (trademarked as Persantine and others) is a nucleoside transport inhibitor and a PDE3 inhibitor medication that inhibits blood clot formation[3][dead link] when given chronically and causes blood vessel dilation when given at high doses over a short time.

  1. ^ Nielsen-Kudsk F, Pedersen AK (May 1979). "Pharmacokinetics of dipyridamole". Acta Pharmacologica et Toxicologica. 44 (5): 391–399. doi:10.1111/j.1600-0773.1979.tb02350.x. PMID 474151.
  2. ^ "Aggrenox (aspirin/extended-release dipyridamole) Capsules. Full Prescribing Information" (PDF). Boehringer Ingelheim Pharmaceuticals, Inc. Retrieved 1 December 2016.
  3. ^ "Dipyridamole" at Dorland's Medical Dictionary

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adenosine at receptor sites. The dose is often decreased in patients on dipyridamole (Persantine) and diazepam (Valium) because adenosine potentiates the...

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headaches, nausea and shortness of breath. It is associated with dipyridamole. Hence, dipyridamole is a pharmacological success diagnostically, but a therapeutic...

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and signaling. Dipyridamole inhibits reuptake of adenosine, resulting in greater extracellular concentrations of adenosine. Dipyridamole also inhibits...

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stroke, treatment with medications such as aspirin, clopidogrel, and dipyridamole may be beneficial. The U.S. Preventive Services Task Force (USPSTF) recommends...

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